18
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T36982 | CXCR3 Antagonist 6c | ||
CXCR3 antagonist 6c is an antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3).1It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 11 (CXCL11) in HEK293 cells expressing the human receptor (IC... | |||
T10297L | AMG 487 | CXCR | |
AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. | |||
T26035 | Rac-NBI-74330 | rac NBI 74330,racNBI74330 | CXCR |
rac-NBI-74330 is an effective and selective CXCR3 antagonist. | |||
T7499 | TAK-779 | Takeda 779 | HIV Protease , CXCR , CCR |
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3). | |||
T3765 | L-asarinin | (-)-Episesamin | Others |
L-asarinin ((-)-Episesamin) reduces peripheral blood concentration of IL-12 and inhibits the expression of CXCR3 and TLR4, which means Asarinin may have a role on the TLR4 pathway and produce prolongation of allograft he... | |||
T3360 | ZK 756326 | ZK756326 2HCl | CCR |
ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 and shows higher 28-fold selectivity over 26 other GPCRs (less ... | |||
T16863 | SCH 546738 | Others | |
SCH 546738 is an effective and non-competitive CXCR3 antagonist. SCH 546738 bindings to the human CXCR3 receptor is determined (Ki: 0.4 nM) in multiple experiments. | |||
T29147 | VUF5834 | VUF-5834,VUF 5834 | |
VUF5834 is a full inverse agonist of CXCR3 N3.35A. | |||
T12567 | PS372424 | Others | |
PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity. | |||
T24949 | VUF10132 | VUF-10132,VUF 10132 | |
VUF10132 is a full inverse CXCR3 N3.35A agonist. | |||
T70616 | ACT-672125 | ||
ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672... | |||
T10297 | AMG 487 (S-enantiomer) | Others | |
AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist. | |||
T35085 | VUF-11222 | VUF 11222 | |
VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2). | |||
T22477 | (±)-AMG 487 | Others | |
AMG 487 is an effective and selective antagonist of chemokine receptor 3. AMG 487 inhibited CXCR3-mediated cell migration induced by three CXCR3 chemokines, IP-10, ITAC and MIG (IC50: 8, 15 and 36 nM, respectively). | |||
T23656 | VUF11211 | VUF-11211,VUF 11211 | |
VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains. | |||
T70411 | PS372424 HCl | ||
PS372424 is a specific agonist of human CXCR3. It has been shown to induce phosphorylation of ERK and block CXCL11 induced migration of CD45+ cells to air pouches generated on humanized mice. | |||
T73148 | ACT-777991 | ||
ACT-777991 is an orally active, selective CXCR3 antagonist with demonstrated stability in microsomes and hepatocytes across various animal models. This compound effectively inhibits the migration of activated T cells tow... | |||
T63761 | ACT-660602 | ||
ACT-660602 is an orally active chemokine receptor CXCR3 antagonist (IC50: 204 nM). ACT-660602 inhibits T cell migration and has shown significant effects in an in vivo model of acute lung injury. ACT-660602 can be used t... |