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Search Results for " cxcr3 "

18

Compounds

Cat No. Product Name Synonyms Targets
T36982 CXCR3 Antagonist 6c
CXCR3 antagonist 6c is an antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3).1It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 11 (CXCL11) in HEK293 cells expressing the human receptor (IC...
T10297L AMG 487 CXCR
AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
T26035 Rac-NBI-74330 rac NBI 74330,racNBI74330 CXCR
rac-NBI-74330 is an effective and selective CXCR3 antagonist.
T7499 TAK-779 Takeda 779 HIV Protease , CXCR , CCR
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
T3765 L-asarinin (-)-Episesamin Others
L-asarinin ((-)-Episesamin) reduces peripheral blood concentration of IL-12 and inhibits the expression of CXCR3 and TLR4, which means Asarinin may have a role on the TLR4 pathway and produce prolongation of allograft he...
T3360 ZK 756326 ZK756326 2HCl CCR
ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 and shows higher 28-fold selectivity over 26 other GPCRs (less ...
T16863 SCH 546738 Others
SCH 546738 is an effective and non-competitive CXCR3 antagonist. SCH 546738 bindings to the human CXCR3 receptor is determined (Ki: 0.4 nM) in multiple experiments.
T29147 VUF5834 VUF-5834,VUF 5834
VUF5834 is a full inverse agonist of CXCR3 N3.35A.
T12567 PS372424 Others
PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity.
T24949 VUF10132 VUF-10132,VUF 10132
VUF10132 is a full inverse CXCR3 N3.35A agonist.
T70616 ACT-672125
ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672...
T10297 AMG 487 (S-enantiomer) Others
AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist.
T35085 VUF-11222 VUF 11222
VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).
T22477 (±)-AMG 487 Others
AMG 487 is an effective and selective antagonist of chemokine receptor 3. AMG 487 inhibited CXCR3-mediated cell migration induced by three CXCR3 chemokines, IP-10, ITAC and MIG (IC50: 8, 15 and 36 nM, respectively).
T23656 VUF11211 VUF-11211,VUF 11211
VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.
T70411 PS372424 HCl
PS372424 is a specific agonist of human CXCR3. It has been shown to induce phosphorylation of ERK and block CXCL11 induced migration of CD45+ cells to air pouches generated on humanized mice.
T73148 ACT-777991
ACT-777991 is an orally active, selective CXCR3 antagonist with demonstrated stability in microsomes and hepatocytes across various animal models. This compound effectively inhibits the migration of activated T cells tow...
T63761 ACT-660602
ACT-660602 is an orally active chemokine receptor CXCR3 antagonist (IC50: 204 nM). ACT-660602 inhibits T cell migration and has shown significant effects in an in vivo model of acute lung injury. ACT-660602 can be used t...
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