Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SCH 546738 is an effective and non-competitive CXCR3 antagonist. SCH 546738 bindings to the human CXCR3 receptor is determined (Ki: 0.4 nM) in multiple experiments.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 854.00 | |
50 mg | 6-8 weeks | $ 1,110.00 | |
100 mg | 6-8 weeks | $ 1,560.00 |
Description | SCH 546738 is an effective and non-competitive CXCR3 antagonist. SCH 546738 bindings to the human CXCR3 receptor is determined (Ki: 0.4 nM) in multiple experiments. |
Targets&IC50 | CXCR3 (human):0.4 nM (ki) |
In vitro | SCH 546738 effectively and specifically inhibits CXCR3-mediated chemotaxis in human activated T cells (IC90: 10 nM). SCH 546738 displaces radiolabeled CXCL10 and CXCL11 from human CXCR3 (IC50: ranging from 0.8 to 2.2 nM) in a non-competitive manner. Competition of human CXCL10 and CXCL11 binding to human CXCR3 by SCH 546738 is determined at various concentrations of [125I]hCXCL10 and [125I]hCXCL11 around the Kd (50-100 pM) for the receptor [1]. |
In vivo | SCH 546738 is a selective and effective CXCR3 antagonist with a good PK for in vivo studies. SCH 546738 has a favorable pharmacokinetic profile in rodents, the plasma concentrations of SCH 546738 in Lewis rat, and C57BL/6 mouse over 24 hr post-dose. SCH 546738 has strong cross-species activities with IC50 of 1.3 nM, 6.4 nM, 5.9 nM, and 4.2 nM in inhibiting the binding of [125I]hCXCL10 to CXCR3 of monkey, dog, mouse and rat origin, respectively [1]. |
Molecular Weight | 492.44 |
Formula | C23H31Cl2N7O |
CAS No. | 906805-42-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.5 mg/mL (9.14 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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SCH 546738 906805-42-3 Others SCH546738 SCH-546738 inhibitor inhibit