ccr4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39661	CCR4 antagonist 3	CCR4 antagonist 3
	CCR4 antagonist 3 is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC 50 s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4 antago...
T60336	CCR4 antagonist 3-1		CCR
	CCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 value of 1.7 μM. CCR4 antagonist 3-1 inhibits the binding of r...		CCR
T39662	CCR4 antagonist 3 hydrochloride
	CCR4 antagonist 3 hydrochloride is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC 50 s of 22 nM and 50 nM in the calcium flux and CTX assa...
T10713	CCR4 antagonist 2		Calcium Channel
	CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the n...		Calcium Channel
T10639	C-021 dihydrochloride		CCR
	C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.		CCR
T21870	C-021	4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-	CCR
	C 021 dihydrochloride is a potent CCR4 antagonist. C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s ...		CCR
T11481	GSK2239633A		CCR
	GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.		CCR
T4300	AZD2098		CCR
	AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.		CCR
T23646	AF 399	AF399,AF-399
	AF 399 is a CCR4 antagonist. It reverses the tumor-promoting environment.
T3360	ZK 756326	ZK756326 2HCl	CCR
	ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 and shows higher 28-fold selectivity over 26 other GPCRs (less ...		CCR
T15641	K777	APC-3316	P450 , Cysteine Protease , CCR
	K777 is a potent, orally active and irreversible inhibitor of cysteine protease. K777 is a potent CYP3A4 inhibitor (IC50= 60 nM). K777 is also a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 ...		P450 , Cysteine Protease , CCR
T11699	J-113863		CCR
	J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptor...		CCR
T68984	AF-399/42018025
	AF-399/42018025 is a CC chemokine receptor 4 (CCR4) antagonist.
T26713	AZD-1678	AZD1678,AZD 1678
	AZD-1678 is a potent CCR4 receptor antagonist.
T76504	CKLF1-C19
	CKLF1-C19, the C-terminal peptide of human chemokine-like factor 1 (CKLF1), interacts with CCR4 and inhibits chemotaxis induced by CKLF1 and CCL17. It also suppresses allergic lung inflammation by inhibiting chemotaxis m...
T69830	GSK2239633
	GSK2239633 is a potent CC-chemokine receptor 4 antagonist with pIC50 of 7.9. The CC-chemokine receptor 4 (CCR4) is thought potentially to play a critical role in asthma pathogenesis due to its ability to recruit type 2...
T69182	APC-3316 hydrochloride
	APC-3316 hydrochloride is a vinyl sulfone cysteine protease inhibitor and selective CCR4 antagonist.
T69183	APC-3316 tosylate
	APC-3316 tosylate is a vinyl sulfone cysteine protease inhibitor and selective CCR4 antagonist.
T76245	CKLF1-C27
	CKLF1-C27, a C-terminal peptide of CKLF1, effectively binds to and activates the CCR4 receptor, thereby triggering the ERK1/2 pathway. It competes with CKLF1 for the CCR4 receptor, neutralizing CKLF1's cellular effects. ...
T76245L	CKLF1-C27 TFA
	CKLF1-C27, a C-terminal peptide of CKLF1, binds to CCR4 receptor and activates ERK1/2 pathway. CKLF1-C27 can abrogate the effect of CKLF1 on cells by competing for CCR4 receptor. CKLF1-C27 shows great effect on promoting...