Powder: -20°C for 3 years | In solvent: -80°C for 1 year
C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 68.00 | |
5 mg | In stock | $ 211.00 | |
10 mg | In stock | $ 317.00 | |
25 mg | In stock | $ 569.00 | |
50 mg | In stock | $ 816.00 | |
100 mg | In stock | $ 1,130.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 271.00 |
Description | C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM. |
In vitro | C-021 (Compound 1b) effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor (IC50: 18 nM). In human liver microsomes (HML), C-021 exhibits CLint value of 17,377 mL/h/kg[1]. |
In vivo | In the murine oxazolone-induced contact hypersensitivity test, the potency of C-021 is evident after subcutaneous administration. When C-021 is administered orally, however, very little inhibition is observed[1]. C-021 (1 mg/kg; i.p.; daily; for 3 days) significantly less microgliosis in acute liver failuremice[2] |
Molecular Weight | 540.57 |
Formula | C27H43Cl2N5O2 |
CAS No. | 1784252-84-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.41 mg/mL (10 mM), Sonification is recommended
You can also refer to dose conversion for different animals. More
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C-021 dihydrochloride 1784252-84-1 Immunology/Inflammation Microbiology/Virology CCR Inhibitor C 021 C 021 dihydrochloride CCL22 CCR4 C 021 Dihydrochloride C021 dihydrochloride C021 CC chemokine receptor C-021 Dihydrochloride inhibit C021 Dihydrochloride C-021 GTPγS chemotaxis inhibitor