brdt — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8932	GSK046	iBET-BD2	Epigenetic Reader Domain
	GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins(IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively). It has immunom...		Epigenetic Reader Domain
T10638	BY27		Epigenetic Reader Domain
	BY27 is a potent and selective BET BD2 inhibitor (Ki: 3.1 nM) with anticancer activity, inhibits BD1/BD2 of BRD2, BRD3, BRD4 and BRDT, and suppresses tumor growth.		Epigenetic Reader Domain
T9703	GSK778		Epigenetic Reader Domain
	GSK778 is a potent and selective inhibitor of BD1 bromodomain such as BRD2 BD1 (IC50s = 75 nM), BRD3 BD1 (IC50s = 41 nM), BRD4 BD1 (IC50s = 41 nM), and BRDT BD1 (IC50s = 143 nM). GSK778 inhibits proliferation, induces a ...		Epigenetic Reader Domain
T22345	INCB054329	INCB-054329,INCB-54329,INCB-54329	Epigenetic Reader Domain
	INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BRDT-BD1 and BRDT-BD2 with IC50 values of 44 nM, 5 nM, 9 nM, ...		Epigenetic Reader Domain
TQ0253	PLX51107		Epigenetic Reader Domain
	PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).		Epigenetic Reader Domain
T72058L	CDD-1102 HCl	CDD-1102 HCl(2757619-84-2 Free base)	Epigenetic Reader Domain
	CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.		Epigenetic Reader Domain
T9703L	GSK778 hydrochloride		Epigenetic Reader Domain
	GSK778 hydrochloride hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 ...		Epigenetic Reader Domain
T10773	CF53		Epigenetic Reader Domain , CDK
	CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT B...		Epigenetic Reader Domain , CDK
T74898	NC-III-49-1
	NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor with significant affinity for several BRD4 and BRDT isoforms, demonstrated by its Kd values of 0.095 nM for BRD4-1, 0.32 nM for BRD4-2...
T75170	BI01826025
	BI01826025 (pArg-JQ1), a PROTAC degrader targeting the bromodomain 1 of BRDT (BRDT BD1), proves useful in exploring the regulatory impact of ClpC2 on the ClpC1P1P2 protease complex [1].
T72058	N1-[5-[[[3-(4-Amino-2-methylphenyl)-1-methyl-1H-indazol-5-yl]carbonyl]amino]-2-methylphenyl]-N4-methyl-1,4-benzenedicarboxamide
	N1-[5-[[[3-(4-Amino-2-methylphenyl)-1-methyl-1H-indazol-5-yl]carbonyl]amino]-2-methylphenyl]-N4-methyl-1,4-benzenedicarboxamide is a potent, selective second bromodomain (BD2) of BRDT and BRD4 inhibitor with IC50 of 7 an...
T74899	GXH-II-052
	GXH-II-052 is a potent bivalent inhibitor targeting the bromodomain and extraterminal domain (BET). It exhibits significant binding affinity to various BET proteins, including BRD4-1, BRD4-2, BRD4-T, BRDT-1, BRDT-2, and ...
T75169	SRG-II-19F
	SRG-II-19F (dCym-JQ1), a BRDT BD1 (bromodomain1 of BRDT) degrader, is utilized to examine the regulatory influence of ClpC2 on the ClpC1P1P2 protease [1].
T79084	BET bromodomain inhibitor 3		Epigenetic Reader Domain
	BET Bromodomain Inhibitor 3 is a BET bromodomain inhibitor with an inhibitory Ki value of >40 µM against BrdT. It is utilized in research related to contraception, cancer, and heart disease [1].		Epigenetic Reader Domain
T69815	SB-284851-BT
	SB-284851-BT is a chemical compound that serves as an inhibitor of BRD4, p38α, and BRDT, exhibiting varying degrees of affinity and inhibition for each. Specifically, it inhibits BRD4-BD1 with an IC50 value of 1.7 µM, p3...
T77588	N-Methyl-N′-[2-methyl-5-[[[1-methyl-3-(pyridin-4-yl)-1H-indazol-5-yl]carbonyl]amino]phenyl]terephthalamide
	N-Methyl-N′-[2-methyl-5-[[[1-methyl-3-(pyridin-4-yl)-1H-indazol-5-yl]carbonyl]amino]phenyl]terephthalamide showed weak affinity for BRDT-BD1 with IC50 values >10 μM.
T74823	Bromodomain IN-2
	BD-IN-1, a pan bromodomain (BD) inhibitor, exhibits K_D values of 250 nM for BRD4(1), 420 nM for CBP, 130 nM for BRPF1B, 430 nM for BRD7, 67 nM for BRD9, 240 nM for BRDT(1), and 970 nM for CECR2, respectively. This compo...
T78851	BRD4 Inhibitor-28		Epigenetic Reader Domain
	BRD4 Inhibitor-28 (Compound 18), an orally active molecule, selectively inhibits the bromodomains of BRD4 (BRD4-BD1 and BRD4-BD2) with IC50 values of 15 and 55 nM, respectively. It also demonstrates inhibition of BRD2-BD...		Epigenetic Reader Domain
T36573	NHWD-870		Apoptosis , Epigenetic Reader Domain
	NHWD-870 is an effective and selective inhibitor of BET family bromodomain only binding to BRD2, BRD3, BRD4 (IC50 = 2.7 nM), and BRDT. NHWD-870 exhibits potent anti-tumor efficacies and suppresses cancer cell-macrophage ...		Apoptosis , Epigenetic Reader Domain
T39998	BET bromodomain inhibitor 1
	BET bromodomain inhibitor 1 is an orally active, selective inhibitor of bromodomain and extra-terminal (BET) proteins. It specifically inhibits BRD4 with an IC50 of 2.6 nM. Additionally, BET bromodomain inhibitor 1 demon...