Home Tools
Log in
Cart

Search Result

Search Results for " brd4-in-4 "

15

Compounds

Cat No. Product Name Synonyms Targets
T77339 BRD4-IN-4 Epigenetic Reader Domain
BRD4-IN-4 is a selective BRD4 inhibitor with an IC50 value of 6.83 μM for BRD4.BRD4-IN-4 selectively inhibits the proliferation of the MV4-11 cell line and arrests the cells in G1 phase.BRD4-IN-4 can be used to study MLL...
T40305 BRD4-IN-2 BRD4-IN-2
BRD4-IN-2 is a bromodomain BRD4 inhibitor with an IC 50 value of 9.9 nM.
T30580 BRD4-Kinases-IN-3 BRD4 kinases inhibitor 3,BRD4-Kinases inhibitor-3
BRD4-Kinases-IN-3 is a dual BRD4-Kinases inhibitor that can be used as a value-added multi-targeted chemical probe for cancer therapy.
T10521 ODM-207 BET-IN-4,ODM207 Epigenetic Reader Domain
ODM-207 (BET-IN-4) is a potent BRD4 inhibitor.
T61318 BRD4 Inhibitor-20 Epigenetic Reader Domain
BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity. BRD4 Inhibitor-20 has antiproliferative activity in cancer cell lines and is used in studies of various cancers, such as colon canc...
T10522 BET-IN-6 Epigenetic Reader Domain
BET-IN-6, a ligand with potent and high affinity for inhibiting BRD2/BRD4, plays a crucial role in the synthesis of PROTAC BRD2/BRD4 degrader-1 [1], targeting the protein BRD2/4.
T63991 BRD4/CK2-IN-1
BRD4/CK2-IN-1 is the first potent, orally active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), acting on both BRD4 (IC50: 180 nM) and CK2 (IC50: 230 nM). In triple-negative breast ...
T72636 BRD4 Inhibitor-26
BRD4 Inhibitor-26, a bromodomain protein 4 (BRD4) inhibitor/nitric oxide-donator, exhibits inhibitory activity against BRD4 (BD1) and BRD4 (BD2) with IC50 values of 0.82 μM and 1.94 μM, respectively. It is utilized in ov...
T78647 PROTAC BRD4 Degrader-16 PROTACs
PROTAC BRD4 Degrader-16 is a potent degrader of BRD4, exhibiting IC50 values of 34.58 nM for BRD4 (BD1) and 40.23 nM for BRD4 (BD2). It significantly reduces Cyclin B1 expression, thereby impeding G2/M phase progression,...
T36628 PROTAC BRD4 Degrader-8 PROTAC BRD4 Degrader-8
PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells...
T74270 PROTAC BRD4 Degrader-17
PROTAC BRD4 Degrader-17 (compound 13i), a potent inhibitor, exhibits IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)), effectively reducing Cyclin B1 expression linked with G2/M phase progression and signifi...
T15399 GNE-207 Epigenetic Reader Domain
GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expres...
T36103 TW9 TW9
TW9 is a dual inhibitor of bromodomain 2 (BD2) in bromodomain-containing protein 4 (BRD4) and histone deacetylase 1 (HDAC1; IC50s = 0.074 and 0.29 μM, respectively).1It is selective for BD2 over BD1 in BRD4 (IC50= 0.72 μ...
T36800 EN219
EN219 is a synthetic recruiter of the E3 ubiquitin ligase RNF114.1It binds to cysteine 8 (C8) in the intrinsically disordered region of RNF114 (RNF114-C8; IC50= 470 nM) and inhibits RNF114-induced autoubiquitination and ...
T38381 CAY17c
CAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50= 0.71 μM), as well as class I histone deacetylases (HDACs; IC50s = 0.046, 0.058, 0.075, and 0.167 μM for HDAC1, -2, -3, and -8, respectively) and cla...
TargetMol