brd4-in-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4365	FL-411	FL 411,FL411,BRD4-IN-1	Epigenetic Reader Domain
	FL-411 (BRD4-IN-1) is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.		Epigenetic Reader Domain
T62030	BRD4-BD1-IN-1
	BRD4-BD1-IN-1 (Compound 9a) is a BRD4-BD1 inhibitor(IC50= 38.20 μM).
T63471	PARP1/BRD4-IN-1
	PARP1/BRD4-IN-1 is a highly selective and potent inhibitor of PARP1 (IC50: 49 nM) and BRD4 (IC50: 202 nM).PARP1/BRD4-IN-1 inhibits the expression and activity of PARP1 and BRD4, thereby synergistically suppressing the ma...
T64058	PLK1/BRD4-IN-1
	PLK1/BRD4-IN-1 (9b) is an orally active dual inhibitor of PLK1 (IC50: 22 nM) and BRD4 (IC50: 109 nM). It has been shown to have good anti-tumour effects in vivo.
T64089	BRD4 D1-IN-1
	BRD4 D1-IN-1 is a selective inhibitor of BRD4 D1 with an IC50 <0.092 μM. BRD4 D1-IN-1 has an affinity of 18 nM and over 500-fold selectivity for BRD4 D1 and BRD4 D2.
T63991	BRD4/CK2-IN-1
	BRD4/CK2-IN-1 is the first potent, orally active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), acting on both BRD4 (IC50: 180 nM) and CK2 (IC50: 230 nM). In triple-negative breast ...
T61791	BRD4-BD1/2-IN-1
	BRD4-BD1/2-IN-1 is a highly effective inhibitor of BRD4, specifically targeting the BRD4 BD-1 and BRD4 BD-2 domains with IC 50 values of <100 nM each (US20150148375A1, compound 5) [1].
T79768	HDAC/JAK/BRD4-IN-1		Epigenetic Reader Domain
	HDAC/JAK/BRD4-IN-1 (compound 25ap) is a potent triple inhibitor targeting HDAC, JAK, and BRD4. This compound not only inhibits cell proliferation but also induces apoptosis in MDA-MB-231 cells and demonstrates in vivo an...		Epigenetic Reader Domain
T10521	ODM-207	BET-IN-4,ODM207	Epigenetic Reader Domain
	ODM-207 (BET-IN-4) is a potent BRD4 inhibitor.		Epigenetic Reader Domain
T6222	PFI-1	PF-6405761,PFI 1,PFI1	Apoptosis , Epigenetic Reader Domain , Autophagy
	PFI-1 (PF-6405761), a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.		Apoptosis , Epigenetic Reader Domain , Autophagy
T19618	(R)-(-)-JQ1 Enantiomer		Epigenetic Reader Domain
	(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)		Epigenetic Reader Domain
T15405	GNE-781		Epigenetic Reader Domain
	GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively).		Epigenetic Reader Domain
T10773	CF53		Epigenetic Reader Domain , CDK
	CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT B...		Epigenetic Reader Domain , CDK
T9619	I-BET567
	I-BET567, a potent pan-BET inhibitor with oral activity, demonstrates pIC50 values of 6.9 and 7.2 for BRD4 BD1 and BD2, respectively. This compound has exhibited efficacy in mouse models of oncology and inflammation [1].
T9703L	GSK778 hydrochloride		Epigenetic Reader Domain
	GSK778 hydrochloride hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 ...		Epigenetic Reader Domain
T36242	PROTAC BRD4 Degrader-5	PROTAC BRD4 Degrader-5
	PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].
T10522	BET-IN-6		Epigenetic Reader Domain
	BET-IN-6, a ligand with potent and high affinity for inhibiting BRD2/BRD4, plays a crucial role in the synthesis of PROTAC BRD2/BRD4 degrader-1 [1], targeting the protein BRD2/4.		Epigenetic Reader Domain
T36628	PROTAC BRD4 Degrader-8	PROTAC BRD4 Degrader-8
	PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells...
T61187	BRD4 Inhibitor-17
	BRD4 Inhibitor-17 (Compound 5i) is a highly potent inhibitor of BRD4, exhibiting an impressive IC50 value of 0.33 μM. It fulfills a crucial regulatory function in transcription by effectively modulating the expression of...
T17477	Azido-PEG1-CH2COO-Cl		Others
	Azido-PEG1-CH2COO-Cl (compound 43a) is an alkyl/ether-based PROTAC linker, commonly employed in the synthesis of PROTAC BRD4 Degrader-1[1].		Others