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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0065 | Acetaminophen | 4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol | COX , Endogenous Metabolite , Histone Acetyltransferase |
Acetaminophen (APAP) is a COX inhibitor that inhibits COX-1 and COX-2 (IC50=113.7/25.8 μM). Acetaminophen has antipyretic and analgesic activity as well as weak anti-inflammatory activity. | |||
T38206 | 3-Cysteinylacetaminophen (trifluoroacetate salt) | APAP-Cys,3-(cysteine-S-yl)acetaminophen,3-Cysteinylacetaminophen (trifluoroacetate salt) | |
3-Cysteinylacetaminophen is an acetaminophen-protein adduct formed during the metabolism of acetaminophen.[1],[2] 3-Cysteinylacetaminophen has been found in isolated human serum following therapeutic and supratherapeutic... | |||
T34785 | TAPAP | 3-Tapap | |
TAPAP binds to thrombin and trypsin. | |||
T7036 | 2,4'-Dihydroxybenzophenone | Antioxidant | |
2,4'-Dihydroxybenzophenone can effectively protect C57BL/6J mice from APAP-induced hepatotoxicity. Its mechanisms might be associated with its Antioxidant activity. | |||
TWS1977 | Kamebakaurin | Kamebakaurine | NF-κB |
1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression... | |||
T82219 | Heilaohuguosu F | ||
Compound 6, known as Heilaohuguosu F, is a tetrahydrofuranolignan demonstrating weak hepatoprotective properties. It exhibits a mild protective effect against acetaminophen (APAP)-induced hepatotoxicity in HepG2 cells. | |||
T82748 | Celosin L | ||
Celosin L, a triterpenoid saponin, demonstrates hepaprotective activity and exerts protective effects against APAP-induced hepatotoxicity in HepG2 cells [1]. | |||
T69218 | PUMAi HCl | ||
PUMAi is an inhibitor of p53 up-regulated modulator of apoptosis (PUMA), a BH3-only Bcl-2 family member, mitigating acetaminophen (APAP)-induced hepatocyte necrosis and liver injury. | |||
T83051 | Anti-inflammatory agent 61 | ||
Compound 5b (Anti-inflammatory agent 61) is a potent anti-inflammatory agent that diminishes TNF-α expression in LPS-induced inflammation within RAW 264.7 cells and mitigates APAP-induced inflammation in HepG2 cells [1]. |