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Search Results for " alk1 "

15

Compounds

Cat No. Product Name Synonyms Targets
T1943 ML347 LDN 193719 ALK , TGF-beta/Smad
ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
T1944 LDN-214117 ALK , TGF-beta/Smad
LDN-214117 is a potent and selective ALK2 inhibitor.
T78128 GALK1-IN-1 Others
Compound 4, known as GALK1-IN-1, is a potent inhibitor of galactokinase, exhibiting an IC50 value of 4.2129 μM [1].
T76858 Ascrinvacumab PF-03446962 ALK , TGF-beta/Smad
Ascrinvacumab (PF-03446962) is a highly humanized IgG2 monoclonal antibody against ALK-1. Ascrinvacumab has a Kd value of 7 nM for human ALK1. Ascrinvacumab has an inhibitory effect on TGF-β and can be used to study hepa...
T1900 LDN-212854 LDN212854,BMP Inhibitor III ALK , TGF-beta/Smad
LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors.
T1914 K02288 K 02288 ALK , TGF-beta/Smad
K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.
T1935 LDN193189 LDN-193189,DM-3189,LDN 193189 ALK , TGF-beta/Smad
LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6).
T35348 LDN-193189 2HCl LDN-193189 2HCl,DM-3189 2HCl ALK , TGF-beta/Smad
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.LDN-193189 2HCl inhibited ...
T1942 DMH-1 DMH1 ALK , Autophagy , TGF-beta/Smad
DMH-1 is a potent and selective BMP inhibitor.
T6158 LDN-193189 HCl LDN193189 Hydrochloride ALK
LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor.
T70176 P7170
P7170 is an anti-cancer agent active as an mTORC1/C2 and activin receptor-like kinase 1 (ALK1) inhibitor.
T73490 MU1700
MU1700, an orally active and potent inhibitor targeting ALK1/2, exhibits IC50 values of 13 nM for ALK1 and 6 nM for ALK2. It demonstrates both cell membrane and high brain permeability.
T21637 SB-505124 hydrochloride
SB-505124 hydrochloride functions as a selective, concentration-dependent inhibitor targeting TGF-β Receptor type I (ALK4, ALK5, ALK7), exhibiting IC50 values of 129 nM for ALK4 and 47 nM for ALK5. Notably, it does not a...
T74660 M4K2234
M4K2234 (compound 26b), an ALK2 inhibitor, demonstrates selective inhibition of ALK2 and ALK5 with IC50 values of 5 nM and 2144 nM, respectively. Serving as a chemical probe for ALK1 and ALK2 protein kinases, M4K2234 hol...
T35896 AZ 12799734 AZ12799734 ALK
AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.
TargetMol