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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1979 | AVN-944 | VX-944 | Dehydrogenase |
AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2. | |||
T71286 | Guaifenesin-d3 | ||
Guaifenesin-d3 is intended for use as an internal standard for the quantification of guaifenesin by GC- or LC-MS. Guaifenesin is an expectorant. It inhibits production of mucin 5AC (MUC5AC), reduces mucus viscosity and e... | |||
T34326 | Ridaifen-B | RidaifenB | |
Ridaifen-B, a tamoxifen derivative, works by inducing independent autophagy of Bcl-2, without estrogen receptor involvement. | |||
T19710 | Ciglitazone | Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878 | Apoptosis , p38 MAPK , PPAR |
Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelia... | |||
T78716 | MKA031 | ||
MKA031 (compound 6y) is a non-competitive inhibitor of macrophage migration inhibitory factor (MIF), exhibiting an IC50 of 1.7 μM. It disrupts the MIF-aryl hydrocarbon receptor interacting protein (AIF) interaction, impe... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8678 | Naphthazarin | 5,8-Dihydroxy-1,4-naphthoquinone,DHNQ | Apoptosis |
Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, inter... | |||
T0739 | Guaifenesin | Glycerol guaiacolate,Guaiacol glyceryl ether,Guaiphenesin | Others |
Guaifenesin (Guaiphenesin) is an expectorant that also has some muscle relaxing action. It is used in many cough preparations. | |||
T75485 | Dehydrobruceine B | ||
Dehydrobruceine B, a quassinoid isolated from Brucea javanica, demonstrates a synergistic effect with Cisplatin in inducing apoptosis through the mitochondrial pathway. It enhances the expression of apoptosis-inducing fa... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00718 | AIF Protein, Human, Recombinant (His) | Human | E. coli |
Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is t... | |||
TMPH-02500 | AIF-1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage acti... | |||
TMPH-00222 | AIF-1 Protein, Bovine, Recombinant (His & Myc) | Bovine | E. coli |
May play a role in macrophage activation and function. AIF-1 Protein, Bovine, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.6 kDa and ... | |||
TMPY-03337 | Iba1 Protein, Human, Recombinant (His) | Human | E. coli |
AIF1, also known as IBA1, is an actin-binding protein. AIF1 is expressed selectively in human macrophage-like cell lines, and in a subset of CD68(+) macrophages in the interstitial and perivascular spaces of human hear... | |||
TMPY-01654 | ITCH Protein, Human, Recombinant (aa 526-903) | Human | E. coli |
E3 ubiquitin-protein ligase Itchy homolog, also known as Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1, NAPP1, and ITCH, is a cell membrane protein that contains one C2 domain, one HECT (E6AP-type E3 ub... | |||
TMPH-00021 | Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His) | Acinetobacter baumannii | P. pastoris (Yeast) |
Porin. Induces apoptosis in human cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as... | |||
TMPH-00022 | Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & SUMO) | Acinetobacter baumannii | E. coli |
Porin. Induces apoptosis in human cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as... | |||
TMPH-00023 | Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & Myc) | Acinetobacter baumannii | E. coli |
Functions as a porin. Induces apoptosis in human cell lines through caspase-dependent and AIF-dependent pathways. Purified Omp38 enters host cell and localizes to the mitochondria, which presumably leads to a release of ... | |||
TMPY-03439 | UBASH3A Protein, Human, Recombinant (aa 354-623, His) | Human | E. coli |
UBASH3A is a member of the T-cell ubiquitin ligand (TULA) family. This family consists of two members. Both of them can negatively regulate T-cell signaling. UBASH3A can facilitate growth factor withdrawal-induced apopto... |