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Targets

5

Compounds

3

Natural Products

9

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T1979 AVN-944 VX-944 Dehydrogenase
AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.
T71286 Guaifenesin-d3
Guaifenesin-d3 is intended for use as an internal standard for the quantification of guaifenesin by GC- or LC-MS. Guaifenesin is an expectorant. It inhibits production of mucin 5AC (MUC5AC), reduces mucus viscosity and e...
T34326 Ridaifen-B RidaifenB
Ridaifen-B, a tamoxifen derivative, works by inducing independent autophagy of Bcl-2, without estrogen receptor involvement.
T19710 Ciglitazone Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878 Apoptosis , p38 MAPK , PPAR
Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelia...
T78716 MKA031
MKA031 (compound 6y) is a non-competitive inhibitor of macrophage migration inhibitory factor (MIF), exhibiting an IC50 of 1.7 μM. It disrupts the MIF-aryl hydrocarbon receptor interacting protein (AIF) interaction, impe...
Cat No. Product Name Synonyms Targets
T8678 Naphthazarin 5,8-Dihydroxy-1,4-naphthoquinone,DHNQ Apoptosis
Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, inter...
T0739 Guaifenesin Glycerol guaiacolate,Guaiacol glyceryl ether,Guaiphenesin Others
Guaifenesin (Guaiphenesin) is an expectorant that also has some muscle relaxing action. It is used in many cough preparations.
T75485 Dehydrobruceine B
Dehydrobruceine B, a quassinoid isolated from Brucea javanica, demonstrates a synergistic effect with Cisplatin in inducing apoptosis through the mitochondrial pathway. It enhances the expression of apoptosis-inducing fa...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00718 AIF Protein, Human, Recombinant (His) Human E. coli
Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is t...
TMPH-02500 AIF-1 Protein, Mouse, Recombinant (His) Mouse E. coli
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage acti...
TMPH-00222 AIF-1 Protein, Bovine, Recombinant (His & Myc) Bovine E. coli
May play a role in macrophage activation and function. AIF-1 Protein, Bovine, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.6 kDa and ...
TMPY-03337 Iba1 Protein, Human, Recombinant (His) Human E. coli
AIF1, also known as IBA1, is an actin-binding protein. AIF1 is expressed selectively in human macrophage-like cell lines, and in a subset of CD68(+) macrophages in the interstitial and perivascular spaces of human hear...
TMPY-01654 ITCH Protein, Human, Recombinant (aa 526-903) Human E. coli
E3 ubiquitin-protein ligase Itchy homolog, also known as Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1, NAPP1, and ITCH, is a cell membrane protein that contains one C2 domain, one HECT (E6AP-type E3 ub...
TMPH-00021 Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His) Acinetobacter baumannii P. pastoris (Yeast)
Porin. Induces apoptosis in human cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as...
TMPH-00022 Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & SUMO) Acinetobacter baumannii E. coli
Porin. Induces apoptosis in human cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as...
TMPH-00023 Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & Myc) Acinetobacter baumannii E. coli
Functions as a porin. Induces apoptosis in human cell lines through caspase-dependent and AIF-dependent pathways. Purified Omp38 enters host cell and localizes to the mitochondria, which presumably leads to a release of ...
TMPY-03439 UBASH3A Protein, Human, Recombinant (aa 354-623, His) Human E. coli
UBASH3A is a member of the T-cell ubiquitin ligand (TULA) family. This family consists of two members. Both of them can negatively regulate T-cell signaling. UBASH3A can facilitate growth factor withdrawal-induced apopto...
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