aβ-in-2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T63689	Aβ-IN-2
	Aβ-IN-2 is a peptide inhibitor of Aβ1-42. Aβ-IN-2 inhibits the in vitro self-aggregation of Aβ1-42 by delaying the growth phase of the Aβ1-42 index or by reducing the number of protofibrils in the steady state.
T63208L	Aβ-IN-1 TFA	Aβ-IN-1 TFA（2766509-32-2 Free base）
	Aβ-IN-1 TFA inhibits and reverses different types of protein aggregation.
T79571	AChE/Aβ-IN-2
	AChE/Aβ-IN-2 (compound 33) is a powerful, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 135 nM. It also functions as an NMDA receptor antagonist (GluN1-1b/GluN2B subunit combination) with an IC50 of...
TN1216	2-O-Acetyl-20-hydroxyecdysone	20-Hydroxyeedysone 2-acetate	Beta Amyloid , Others
	2-O-Acetyl-20-hydroxyecdysone is an ecdysone present in insects and terrestrial plants. 2-O-Acetyl-20-hydroxyecdysone inhibits amyloid-β42-induced cytotoxicity and is able to reduce the formation of Aβ oligomers by promo...		Beta Amyloid , Others
T77162	Donanemab
	Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody targeting a pyroglutamate amyloid beta (Aβ) epitope at the N-terminus. It shows promise for research in early Alzheimer's disease [1] [2].
T22694	CRANAD 2		Others
	CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-f...		Others
T3394	Timosaponin BII	Prototimosaponin A III	Beta Amyloid , Others , BACE
	Timosaponin BII (Prototimosaponin A III) has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-regulation of BACE1 and reduced the...		Beta Amyloid , Others , BACE
T3S0645	N-trans-Feruloyltyramine	Feruloyltyramine,N-Feruloyltyramine,Moupinamide	Others , COX
	1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s...		Others , COX
T4956	Tetrahydroxystilbene-2-O-β-D-glucoside	tetrahydroxyl diphenylethylene-2-o-gluco,EH-201	Others
	Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) is a low MW inducer of erythropoietin. Tetrahydroxystilbene-2-O-β-D-glucoside induces expression of erythropoietin, PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astroc...		Others
T11359	Gamma-secretase modulator 2		Others
	Gamma-secretase modulator 2 is a potent, selective compound for the treatment of Alzheimer's disease, specifically designed to modulate γ-secretase activity. This modulation selectively attenuates the production of Aβ(1-...		Others
T37369	Amyloid-β (1-8, A2V) Peptide	Amyloid-β (1-8, A2V) Peptide
	Amyloid-β (1-8, A2V) is a truncated form of amyloid-β (Aβ) that contains a valine to alanine substitution at position 2 of the Aβ numbering convention (Aβ A2V), which corresponds to position 673 of the amyloid precursor ...
T60691	AChE/BChE/BACE-1-IN-2
	AChE/BChE/BACE-1-IN-2 (Compound 4o) exhibits remarkable antioxidant potential and considerable binding capability towards PAS-AChE. AChE/BChE/BACE-1-IN-2 is an orally active AChE, BACE-1 and BChE inhibitor with IC 50 val...
T76424	(Gly22)-Amyloid β-Protein (1-42)
	(Gly22)-Amyloid β-Protein (1-42), a peptide fragment of Amyloid β-Protein (Aβ), plays a crucial role in Alzheimer's disease by forming the main component of both vascular and parenchymal amyloid deposits. The mutation fr...
T63995	BuChE-IN-2
	BuChE-IN-2 is an excellent inhibitor of butylcholinesterase (BuChE), acting on BuChE (IC50: 1.28 μM) and NO (IC50: 0.67 μM). BuChE-IN-2 inhibits Aβ aggregation, ROS formation and Cu2+ chelation, exhibits proper blood-bra...
T83451	14,15-Epoxyeicosatrienoic acid	14,15-EET
	14,15-Epoxyeicosatrienoic acid (14,15-EET), derived from Arachidonic acid metabolism, significantly inhibits platelet aggregation in vivo and enhances astrocytic Aβ clearance, making it relevant for Alzheimer's Disease r...
T79994	7-Deoxy-trans-dihydronarciclasine
	7-Deoxy-trans-dihydronarciclasine is an alkaloid that functions as a tobacco mosaic virus (TMV) inhibitor with an IC50 of 1.80 μM and also serves as an anti-neuroinflammatory agent. This compound reduces Aβ and APP level...
T60837	AChE/BuChE-IN-2
	AChE/BuChE-IN-2 (Compound 5f) can cross the BBB that is an orally active inhibitor of AChE and BuChE with IC 50 values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows potent inhibition of self-induced β-amyl...
T76425	(Glu20)-Amyloid β-Protein (1-42)
	(Glu20)-Amyloid β-Protein (1-42) represents a variant of amyloid β-protein (Aβ) that fibrillizes more slowly. This is attributed to the Glu20 mutation, which diminishes Aβ42's tendency to aggregate and inhibits the accum...
T64214	NXPZ-2
	NXPZ-2 is an orally active Keap1-Nrf2protein-protein interaction (PPI) inhibitor (Ki: 95 nM, EC50: 120 and 170 nM). NXPZ-2 dose-dependently attenuates Aβ[1-42]-induced cognitive disturbances, enhances neuronal number and...
T72763	AChE/BuChE-IN-1
	AChE/BuChE-IN-1, a selective butyrylcholinesterase (BuChE) inhibitor derived from chrysin, exhibits a potent efficacy with an IC50 of 0.48 μM against BuChE and a lesser inhibitory effect on acetylcholinesterase (AChE) wi...