Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation.
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Description | CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation. |
In vitro | CP5V induces degradation of Cdc20 leading to significant inhibition of breast cancer cell proliferation and resensitization of Taxol-resistant cell lines. CP5V profoundly degrades Cdc20 in both MCF7 and MDA-MB-231 cells (DC50: about 1.6 μM). |
Molecular Weight | 1075.49 |
Formula | C46H66Cl3N9O12S |
CAS No. | 2509359-75-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CP5V 2509359-75-3 Others CP-5V inhibitor inhibit