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AXL Protein, Human, Recombinant (His & Avi)
(Synonyms: UFO, Tyro7, JTK11, EC 2.7.10.1, EC 2.7.10, AXL oncogene, Axl, ARK, AI323647) Copy Product InfoSynonyms: UFO, Tyro7, JTK11, EC 2.7.10.1, EC 2.7.10, AXL oncogene, Axl, ARK, AI323647
Catalog No. TMPK-00407 Copy Product Info
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 48.7 kDa and the accession number is P30530-1.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $30 | 7-10 days | 7-10 days | |
| 10 μg | $44 | 7-10 days | 7-10 days | |
| 20 μg | $67 | 7-10 days | 7-10 days | |
| 50 μg | $126 | 7-10 days | 7-10 days | |
| 100 μg | $207 | 7-10 days | 7-10 days | |
| 200 μg | $376 | 7-10 days | 7-10 days | |
| 500 μg | $838 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Human AXL, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-AXL Antibody, hFc Tag with the EC50 of 15.5ng/ml determined by ELISA. |
| Description | Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 48.7 kDa and the accession number is P30530-1. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His-Avi |
| Accession Number | P30530-1 |
| Construction | Ala26-Pro449 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by SEC-HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | UFO, Tyro7, JTK11, EC 2.7.10.1, EC 2.7.10, AXL oncogene, Axl, ARK, AI323647 |
| Research Background |
| Molecular Weight | 48.7 kDa (predicted). Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result. |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: AXL Protein, Human, Recombinant (His & Avi) chemical structure | AXL Protein, Human, Recombinant (His & Avi) molecular weight
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