store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ziresovir (RO-0529) is a respiratory syncytial virus fusion protein (RSV F) inhibitor that inhibits RSV activity and can be used in the study of syncytial virus sensing.
Pack Size | Availability | Price/USD | Quantity |
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1 mg | In stock | $ 149.00 |
Description | Ziresovir (RO-0529) is a respiratory syncytial virus fusion protein (RSV F) inhibitor that inhibits RSV activity and can be used in the study of syncytial virus sensing. |
Targets&IC50 | RSV F:3 nM (EC50) |
In vitro | With EC50/EC90 values (μM) of 0.003/0.005 (WT), 2.1/10.0 (D486N), and >10/>10 (D489A), Ziresovir exhibits different efficacy in Wild Type (WT) and Mutant Strains RSV, respectively[1].Inhibiting the RSV F protein-induced cell–cell fusion process, RO-0529 (100 nM; 4 d) suppresses the syncytia formation induced by the RSV F protein[1]. |
In vivo |
Ziresovir (12.5 mg/kg, 50 mg/kg; p.o.; twice daily; 4 d) leads to a reduction of RSV titer in the mouse lung[1]. With a single dose of 10 mg/kg administered orally, Ziresovir exhibits good oral exposure and bioavailability, with an F(%) of 32% in male Wistar-Han rats[1]. Following a single oral dose of 150 mg/kg, Ziresovir demonstrates higher tissue distribution to the lung than plasma in CD-1 mice[1]. |
Synonyms | AK0529, RO-0529 |
Molecular Weight | 439.53 |
Formula | C22H25N5O3S |
CAS No. | 1422500-60-4 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (227.52 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Ziresovir 1422500-60-4 Microbiology/Virology RSV RO 0529 RO0529 AK0529 AK-0529 RO-0529 AK 0529 inhibitor inhibit