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RSV604

Catalog No. T7353   CAS 676128-63-5
Synonyms: (S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea

RSV604 ((S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea) is an inhibitor of respiratory syncytial virus (RSV) that binds to RSV nucleoprotein (Kd = 1.31 μM)

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RSV604 Chemical Structure
RSV604, CAS 676128-63-5
Pack Size Availability Price/USD Quantity
2 mg In stock $ 34.00
5 mg In stock $ 55.00
10 mg In stock $ 97.00
25 mg In stock $ 198.00
50 mg In stock $ 395.00
100 mg In stock $ 652.00
200 mg In stock $ 915.00
1 mL * 10 mM (in DMSO) In stock $ 61.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description RSV604 ((S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea) is an inhibitor of respiratory syncytial virus (RSV) that binds to RSV nucleoprotein (Kd = 1.31 μM)
Targets&IC50 nucleocapsid protein:1.6 μM (Kd)
In vitro RSV-604 increases viability of RSV-infected HEp-2 cells (EC50 = 0.86 μM) and inhibits RSV replication in human airway epithelial (HAE) cell monolayers following mucosal inoculation[1].
In vivo RSV604 resistance mutations in the N protein. RSV604 engaged in two different MoAs in HeLa cells, inhibiting both RSV RNA synthesis and the infectivity of released virus. RSV604 did not inhibit viral RNA synthesis in the RSV subgenomic replicon cells or in the cell-free RNP assay, suggesting that it might act prior to viral replication complex formation. RSV604 did not alter N protein localization in the infected cells[2].
Synonyms (S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea
Molecular Weight 388.39
Formula C22H17FN4O2
CAS No. 676128-63-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 195 mg/mL (502.07 mM)

TargetMolReferences and Literature

2. Challa S, Scott AD, Yuzhakov O,et al.Mechanism of Action for Respiratory Syncytial Virus Inhibitor RSV604[J].Antimicrob Agents Chemother. 2015 Feb 3. RSV604, a Novel Inhibitor of Respiratory Syncytial Virus Replication[J]. Antimicrobial Agents and Chemotherapy, 2007, 51(9):3346-3353.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Drug Repurposing Compound Library Immunology/Inflammation Compound Library Covalent Inhibitor Library ReFRAME Related Library Inhibitor Library Anti-Viral Compound Library Bioactive Compounds Library Max Clinical Compound Library Anti-Infection Compound Library

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Keywords

RSV604 676128-63-5 Microbiology/Virology RSV virus (S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea Respiratory syncytial virus A 60444 respiratory protein inhibit RSV 604 syncytial A-60444 RSV-604 Inhibitor A60444 nucleocapsid inhibitor

 

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