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ZD-0892

Name: ZD-0892
Brand: TargetMol
SKU: T13389
Price: 119 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13389Cas No. 171964-73-1

ZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.

ZD-0892

🥰Excellent

Purity: 99.53%

Catalog No. T13389Cas No. 171964-73-1

ZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.

Pack Size	Price	Availability
1 mg	$119	In Stock
5 mg	$293	In Stock
10 mg	$483	In Stock
25 mg	$896	In Stock
50 mg	$1,230	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.53%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	ZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.
Targets&IC50	Neutrophil elastase (pig):200 nM (Ki), Neutrophil elastase (human):6.7 nM (Ki)
In vitro	Neutrophils incubated with ZD-0892 (20µM) for 1 hour were found to be resistant to superoxide, hypochlorite, hydrogen peroxide, hydroxyl radical and peroxynitrite-mediated degradation and had no effect on the formation of these oxidants by activated neutrophils.[3]
In vivo	Administration of ZD0892 to DBA/2 mice infected with EMC virus reduces myocardial elastolytic activity and coronary microvascular perfusion injury.ZD0892 reduces the pathological severity of myocardial lesions associated with viral myocarditis in mice[1].ZD-0892 reverses advanced pulmonary vascular disease produced in rats[2].

Chemical Properties

Molecular Weight	499.52
Formula	C₂₄H₃₂F₃N₃O₅
Cas No.	171964-73-1
Smiles	COc1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
Relative Density.	1.227 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (300.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0019 mL	10.0096 mL	20.0192 mL	100.0961 mL
5 mM	0.4004 mL	2.0019 mL	4.0038 mL	20.0192 mL
10 mM	0.2002 mL	1.0010 mL	2.0019 mL	10.0096 mL
20 mM	0.1001 mL	0.5005 mL	1.0010 mL	5.0048 mL
50 mM	0.0400 mL	0.2002 mL	0.4004 mL	2.0019 mL
100 mM	0.0200 mL	0.1001 mL	0.2002 mL	1.0010 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc