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Triciribine phosphate

Catalog No. T19699 CAS 61966-08-3

Synonyms: TCN-P, VD 002, VQD-002

Triciribine phosphate (VD 002) is a highly selective AKT inhibitor that induces cell cycle arrest and cysteinyl asparagin-dependent apoptosis, inhibits neovascularization, and can be used in the study of leukemia.

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Triciribine phosphate Chemical Structure

Triciribine phosphate, CAS 61966-08-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 293.00
5 mg	In stock	$ 722.00
10 mg	In stock	$ 987.00
25 mg	In stock	$ 1,520.00
50 mg	In stock	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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Purity: 99.43%

ee: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	TCN-P, VD 002, VQD-002
Molecular Weight	400.28
Formula	C13H17N6O7P
CAS No.	61966-08-3

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1 mg/mL (2.50 mM), Sonication is recommended.

H2O: 5 mg/mL (12.49 mM), Sonication is recommended.

References and Literature

1. E C Moore, Inhibition of two enzymes in de novo purine nucleotide synthesis by triciribine phosphate (TCN-P). Biochem Pharmacol. 1989, 38, 22. 2. Kim R,et al. Triciribine Phosphate Monohydrate, an AKT Inhibitor, Enhances Gemcitabine Activity in Pancreatic Cancer Cells. Anticancer Res. 2015 Sep;35(9):4599-604. 3. Wu H,et al. Pharmacological inhibiting STAT5 for the treatment of FLT3-ITD-positive acute myeloid leukemia with triciribine phosphate monohydrate. MedComm (2020). 2023 Jun 21;4(4):e294. 4. Garrett CR,et al. Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT. Invest New Drugs. 2011 Dec;29(6):1381-9. 5. Sampath D,et al. Phase I clinical, pharmacokinetic, and pharmacodynamic study of the Akt-inhibitor triciribine phosphate monohydrate in patients with advanced hematologic malignancies. Leuk Res. 2013 Nov;37(11):1461-7.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Triciribine phosphate 61966-08-3 Apoptosis Cytoskeletal Signaling PI3K/Akt/mTOR signaling Akt PTX 200 PTX200 TCN-P VQD002 VD 002 PTX-200 VQD 002 VQD-002 inhibitor inhibit

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