Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tazemetostat hydrobromide (E-7438 hydrobromide) is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki: 2.5 nM). Tazemetostat hydrobromide also inhibits EZH1 (IC50: 392 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 36.00 | |
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 74.00 | |
50 mg | In stock | $ 97.00 | |
100 mg | In stock | $ 162.00 | |
200 mg | In stock | $ 243.00 | |
500 mg | In stock | $ 397.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 76.00 |
Description | Tazemetostat hydrobromide (E-7438 hydrobromide) is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki: 2.5 nM). Tazemetostat hydrobromide also inhibits EZH1 (IC50: 392 nM). |
Targets&IC50 | EZH2 (rat):4 nM, EZH2:11 nM (in peptide assay), EZH2:16 nM (in nucleosome assay), EZH2 (WT):2.5 nM (Ki), EZH1:392 nM |
In vitro | Tazemetostat hydrobromide inhibits Rat EZH2 (IC50: 4 nM). Tazemetostat hydrobromide inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat hydrobromide inhibits multi wild-type and mutant lymphoma cell lines proliferation with IC50s of 0.49 nM-7.6 μM [1]. |
In vivo | Tazemetostat (250 or 500 mg/kg twice daily for 21-28 days) practically eliminates the fast-growing G401 tumors [1]. |
Synonyms | E-7438 hydrobromide, EPZ-6438 hydrobromide |
Molecular Weight | 653.65 |
Formula | C34H45BrN4O4 |
CAS No. | 1467052-75-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (152.99 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tazemetostat hydrobromide 1467052-75-0 Chromatin/Epigenetic Histone Methyltransferase Tazemetostat EPZ 6438 Hydrobromide E 7438 EPZ-6438 Hydrobromide E7438 E-7438 hydrobromide PRC2 Inhibitor E-7438 epigenetic Tazemetostat Hydrobromide EZH2 EPZ6438 EPZ6438 Hydrobromide EPZ-6438 cancer EPZ-6438 hydrobromide E 7438 Hydrobromide E-7438 Hydrobromide E7438 Hydrobromide EPZ 6438 inhibit EZH1 inhibitor