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Tanshinone IIA

Catalog No. T2906   CAS 568-72-9
Synonyms: Tanshinone B, Dan Shen ketone

Tanshinone IIA (Tanshinone B)(Tanshinone B) is the diterpene quinone in Danshen, which is utilized in the treatment of cardiovascular and inflammatory.

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Tanshinone IIA Chemical Structure
Tanshinone IIA, CAS 568-72-9
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Purity: 100%
Purity: 99.54%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Tanshinone IIA (Tanshinone B)(Tanshinone B) is the diterpene quinone in Danshen, which is utilized in the treatment of cardiovascular and inflammatory.
Cell Research Tanshinone IIA (Tan IIA) is dissolved in DMSO (10 mM) and stored (in dark and -20°C), and serially diluted in a RPMI 1640 medium immediately prior to experiments[1]. A549 cells are counted in logarithmic phase and 6000 cells (90 μL volume) are placed in 96-well plates. 10 μL varying concentrations of Tanshinone IIA (final concentrations 80, 60, 40, 30, 20, 15, 10, 5 and 2.5 μM) and ADM (final concentrations 8, 4, 2, 1, 0.5 and 0.25 μM) are added into drug groups, while negative control group (vehicle group) is only added 10 μL DMSO or normal saline without Tanshinone IIA or ADM. Cells are incubated for an additional 2 h with CCK-8 reagent (100 μL/mL medium) and the absorbance is read at 450 nm using a microplate reader. Cell proliferation inhibition rates are calculated according to the following formula: the proliferation inhibition ratio (%)=1-[(A1-A4)/(A2-A3)]×100, where, A1 is the OD value of drug experimental group, A2 is the OD value of blank control group, A3 is the OD value of the RPMI1640 medium without cells, and A4 is the OD value of drugs with the same concentration as A1 but without cells. The IC50 value, which represents the concentration of the drug that demonstrates 50% of cell growth inhibition, is calculated by nonlinear regression analysis using GraphPad Prism software[1].
Source
Synonyms Tanshinone B, Dan Shen ketone
Molecular Weight 294.34
Formula C19H18O3
CAS No. 568-72-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.94 mg/mL (10 mM), The compound is unstable in solution and is recommended to be prepared and used immediately.

TargetMolReferences and Literature

1. Fu J, et al. Eur J Pharmacol, 2007, 568(1-3), 213-221. 2. Wang X, et al. Int J Cancer, 2005, 116(5), 799-807. 3. Sun S, et al. Brain Res Bull, 2012, 88(6), 581-588. 4. Ruolin Yang, et al. Med. Chem. Commun., 2014, 5: 1528-1532. 6. Zhang Z, et al. Tanshinone IIA inhibits apoptosis in the myocardium by inducing microRNA-152-3p expression and thereby downregulating PTEN. Am J Transl Res. 2016 Jul 15;8(7):3124-32. 7. Su CC, et al. Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo. Oncol Rep. 2016 Aug;36(2):1173-9.

TargetMolCitations

1. Huang Y, Yu S H, Zhen W X, et al. Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2. Theranostics. 2021, 11(14): 6891

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Tyrosine Kinase Inhibitor Library Miao medicine Compound Library Natural Product Library for HTS Clinical Compound Library Target-Focused Phenotypic Screening Library Anti-Breast Cancer Compound Library Natural Product Library ReFRAME Related Library

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Keywords

Tanshinone IIA 568-72-9 Angiogenesis Tyrosine Kinase/Adaptors VEGFR inhibit Tanshinone B Dan Shen ketone Vascular endothelial growth factor receptor Inhibitor inhibitor

 

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