Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 35.00 | |
5 mg | In stock | $ 57.00 | |
10 mg | In stock | $ 83.00 | |
25 mg | In stock | $ 128.00 | |
50 mg | In stock | $ 218.00 | |
100 mg | In stock | $ 410.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 63.00 |
Description | TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells. |
Targets&IC50 | MTH1:5 nM |
In vitro | In mice carrying xenografts with the BRAFV600E mutation, TH588 (30 mg/kg, subcutaneously) reduces tumor growth rates. Additionally, in mice bearing SW480 colon or MCF7 breast cancer xenografts, TH588 (30 mg/kg, subcutaneously) inhibits MTH1, resulting in decreased tumor growth. |
In vivo | TH588 induces DNA damage in U2OS cells, triggering ATM-p53-mediated DNA repair and apoptotic responses. It exhibits selective cytotoxicity towards U2OS and other cancer cell lines while showing minimal toxicity towards several primary or immortalized cell lines. |
Molecular Weight | 295.17 |
Formula | C13H12Cl2N4 |
CAS No. | 1609960-31-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (93.13 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TH588 1609960-31-7 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis MTH1 TH-588 inhibit Inhibitor TH 588 inhibitor