Powder: -20°C for 3 years | In solvent: -80°C for 1 year
T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the <800-fold selectivity over PPARα and PPARδ.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 45.00 | |
10 mg | In stock | $ 53.00 | |
25 mg | In stock | $ 93.00 | |
50 mg | In stock | $ 150.00 | |
100 mg | In stock | $ 207.00 | |
200 mg | In stock | $ 269.00 | |
500 mg | In stock | $ 453.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ. |
Targets&IC50 | PPARγ:1 nM |
In vivo | T0070907 can attenuate the beneficial effects of lipopolysaccharide pretreatment, such as significantly improving renal insufficiency, reducing hepatocyte damage and circulatory failure, and reducing plasma interleukin-1 elevation caused by severe endotoxemia. |
Kinase Assay | Ligand Binding Assay: To determine the binding affinity of T0070907 to the PPARs, scintillation proximity assay (SPA) is performed with the following modifications. A 90-μl reaction contains SPA buffer (10 mm KH2PO4, 10 mm KH2PO4, 2 mm EDTA, 50 mm NaCl, 1 mm dithiothreitol, 2 mmCHAPS, 10% (v/v) glycerol, pH 7.1), 50 ng of GST-PPARγ (or 150 ng of GST-PPARα, GST-PPARδ), 5 nm 3H-labeled radioligands, and 5 μl of T0070907 in Me2SO. After incubation for 1 h at room temperature, 10 μl of polylysine-coated SPA beads (at 20 mg/ml in SPA buffer) are added, and the mixtureis incubated for 1 h before reading in Packard Topcount. [3H]Rosiglitazone is used for PPARγ, and [3H]GW2433 is used for PPARα and PPARδ. |
Cell Research | MTS assay(Only for Reference) |
Molecular Weight | 277.66 |
Formula | C12H8ClN3O3 |
CAS No. | 313516-66-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.8 mg/mL (100 mM)
1eq. HCl: 27.8 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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T0070907 313516-66-4 DNA Damage/DNA Repair Metabolism PPAR inhibit T 0070907 Inhibitor T-0070907 Peroxisome proliferator-activated receptors inhibitor