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Succinobucol

Catalog No. T4287 CAS 216167-82-7

Synonyms: Probucol monosuccinate, AGI-1067

Succinobucol (Probucol monosuccinate) is a novel phenolic antioxidant small molecule with anti-oxidant and anti-inflammatory properties. It designed to treat atherosclerosis of the blood vessels of the heart or coronary artery disease.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Succinobucol, CAS 216167-82-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 163.00
50 mg	In stock	$ 278.00
100 mg	In stock	$ 476.00
500 mg	In stock	$ 1,050.00
1 mL * 10 mM (in DMSO)	In stock	$ 64.00

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Purity: 99.96%

Purity: 98.8%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Succinobucol (Probucol monosuccinate) is a novel phenolic antioxidant small molecule with anti-oxidant and anti-inflammatory properties. It designed to treat atherosclerosis of the blood vessels of the heart or coronary artery disease.
In vitro	In rabbit whole blood, Succinobucol (10, 50, 100 μM) causes a dose-dependent reduction in collagen-induced platelet aggregation. Succinobucol (10, 100 μM) significantly lowers the relaxation to X/XO.
In vivo	In lung metastatic breast cancer mice, Succinobucol (40 mg/kg) by tail injection significantly reduces the average number of metastatic nodules. In rats, Succinobucol (50, 100, and 150 mg/kg, i.v.) has no significant effect on either heart rate or MAP.
Cell Research	In the metastatic 4T1 breast cancer cells, Succinobucol, SCB and the PCD polymer (equivalent concentration to SCB) are respectively added to each well with SCB concentrations ranging from 4 ng/mL to 40 μg/mL.
Animal Research	Mice, injected 4T1-luc cells, are treated with Succinobucol (40 mg/kg) by tail injection every three days.

Synonyms	Probucol monosuccinate, AGI-1067
Molecular Weight	616.91
Formula	C35H52O5S2
CAS No.	216167-82-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 162.1 mM

References and Literature

1. Houston SA, et al. An investigation of the antiplatelet effects of succinobucol (AGI-1067). Platelets. 2017 May;28(3):295-300 2. Colle D, et al. Succinobucol, a Lipid-Lowering Drug, Protects Against 3-Nitropropionic Acid-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Cells via Upregulation of Glutathione Levels and Glutamate Cysteine Ligase Activity. Mol Neurobiol. 2016 Mar;53(2):1280-95. 3. Dan Z, et al. A pH-Responsive Host-guest Nanosystem Loading Succinobucol Suppresses Lung Metastasis of Breast Cancer. Theranostics. 2016 Jan 25;6(3):435-45.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Kinase Inhibitor Library Anti-Liver Cancer Compound Library Anti-Breast Cancer Compound Library Anti-Cancer Compound Library Oxidation-Reduction Compound Library Bioactive Compound Library Ferroptosis Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Succinobucol 216167-82-7 Immunology/Inflammation Metabolism NF-Κb oxidation-reduction Reactive Oxygen Species Antioxidant Inhibitor inhibit Probucol monosuccinate Probucol Monosuccinate AGI1067 AGI-1067 Probucol AGI 1067 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.