keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 52.00 | |
5 mg | In stock | $ 118.00 | |
10 mg | In stock | $ 188.00 | |
25 mg | In stock | $ 400.00 | |
50 mg | In stock | $ 595.00 | |
100 mg | In stock | $ 849.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 313.00 |
Description | Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family. |
In vitro | The process involves the desensitization and resensitization of neuropeptide substance P (SP) through the neurokinin 1 receptor (NK1-R), which may relate to the endocytosis and recycling of NK1-R. Both SP and NK1-R are internalized into clathrin-immunoreactive vesicles and subsequently segregated into distinct compartments. Initially, SP remains intact on the cell surface and in early endosomes but gradually degrades in perinuclear vesicles. SP triggers the clathrin-dependent internalization of NK1-R. Within acidified endosomes, the SP/NK1-R complex disassociates, leading to the degradation of SP while NK1-R is recycled back to the cell surface. This mechanism of SP-induced NK1-R internalization is observed in transfected epithelial cells[1]. |
Synonyms | Neurokinin P |
Molecular Weight | 1347.63 |
Formula | C63H98N18O13S |
CAS No. | 33507-63-0 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10mM
You can also refer to dose conversion for different animals. More
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Substance P 33507-63-0 GPCR/G Protein Metabolism Neuroscience Neurokinin receptor Endogenous Metabolite Neurokinin P Tachykinin receptor Neurokinin Receptor Inhibitor NK receptor inhibit inhibitor