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Metabolism AhR StemRegenin 1

StemRegenin 1

Catalog No. T1831   CAS 1227633-49-9
Synonyms: SR1

StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor.

StemRegenin 1, CAS 1227633-49-9
Pack Size Availability Price/USD Quantity
5 mg In stock 44.00
10 mg In stock 58.00
25 mg In stock 139.00
50 mg In stock 185.00
100 mg In stock 336.00
200 mg In stock 605.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor.
Targets&IC50 AhR : ic50 127nM,   Aryl hydrocarbon receptor (AhR),  
Cell Research
StemRegenin 1 (SR1) is prepared in DMSO and stored, and then diluted with appropriate medium before use[1]. A quantity of 250,000 CB-derived CD34+ cells are cultured with control conditions (DMSO, 0.01%) or StemRegenin 1 (0.75 μM) for 3 weeks. At this point control cultures had expanded 1080-fold and StemRegenin 1 treated cells expanded 2024-fold relative to starting cell numbers. A quantity of 30 to 30,000 uncultured CD34+ CB-derived cells or a fraction of the final culture equivalent to 30 to 10,000 starting cells are transplanted. The cells are injected intravenously via the retro-orbital route into sub-lethally irradiated (300 rads, 200 rads) 6- to 10-week-old NSG mice. Engraftment is performed within 24 h after irradiation. Engraftment is monitored by flow cytometric analysis of blood obtained via retro-orbital sinus or bone marrow using anti-human CD45 and anti-mouse CD45 antibodies. The mice are sacrificed between 13-16 weeks posttransplantation; bone marrow (from both femurs and tibiae), spleen and thymus are collected for analysis. For secondary engraftment, 50% of the bone marrow from each recipient mouse is transplanted into one secondary sub-lethally irradiated NSG mouse. Fifteen weeks after transplantation, bone marrow is harvested from the secondary mice and analyzed by flow cytometry[1].
Synonyms SR1
Purity 98.00%
Molecular Weight 429.54
Formula C24H23N5OS
CAS No. 1227633-49-9

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 80 mg/mL (186.2 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Boitano AE, et al. Science, 2010, 329(5997), 1345-1348. 2. Gao H, et al. J Biol Chem, 2012, 287(35), 219979-291987. 3. Gori JL, et al. Blood, 2012, 120(13), e35-44.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Stem cell Differentiation Compound Library Bioactive Lipid Compound Library Anti-Metabolism Disease Compound Library

Related Products

Related compounds with same targets
Nimodipine 1,4-Chrysenequinone Mexiletine hydrochloride Leflunomide StemRegenin 1 YL109 CH 223191 CAY10465

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