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Squalene

Name: Squalene
Brand: TargetMol
SKU: T4749
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4749Cas No. 111-02-4

Alias Super Squalene, AddaVax

Squalene (AddaVax) is an intermediate in cholesterol synthesis. Squalene has a variety of pharmacological properties, such as antilipemic, hepatoprotective, anti-atherosclerotic, cardioprotective, antioxidant, antitumor and antifungal.

Squalene

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Purity: 99.33%

Catalog No. T4749Alias Super Squalene, AddaVaxCas No. 111-02-4

Pack Size	Price	Availability
10 mg	$30	In Stock
25 mg	$39	In Stock
50 mg	$64	In Stock
100 mg	$89	In Stock
200 mg	$128	In Stock
500 mg	$219	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock

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Purity:99.33%

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COA HNMR GC

Product Introduction

Bioactivity

Description	Squalene (AddaVax) is an intermediate in cholesterol synthesis. Squalene has a variety of pharmacological properties, such as antilipemic, hepatoprotective, anti-atherosclerotic, cardioprotective, antioxidant, antitumor and antifungal.
Targets&IC50	HepG2 cells:100 μg/ml, JURKAT cells:26.22 μg/ml
In vitro	METHODS: Human MCF7, NCI-H460, and SF-268 cells were treated with Squalene (0-50 μM) for 72 hours, and MTS reduction assay was used to detect cell growth inhibition. RESULTS: Squalene did not inhibit the proliferation of MCF7, NCI-H460 and SF-268 cells (IC50>50 μM). [1] METHODS: MCF10A epithelial cells were treated with Squalene (12.5, 50, and 200 μM) for 24 hours, and ROS levels were measured using a microplate reader. RESULTS: Squalene reduced intracellular ROS levels. [2]
In vivo	METHODS: To study the effect of Squalene on lipid parameters, mice were fed a diet containing Squalene (0.25-1 g/kg) for 11 weeks. RESULTS: Squalene promoted the changes of HDL-cholesterol and paraoxonase 1, and decreased the reactive oxygen species in lipoproteins and plasma malondialdehyde levels. [3]
Synonyms	Super Squalene, AddaVax

Chemical Properties

Molecular Weight	410.72
Formula	C₃₀H₅₀
Cas No.	111-02-4
Smiles	CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C
Relative Density.	> 0.855 - < 0.865. Temperature:20 °C.

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 100 mg/mL (243.47 mM)

DMSO: 100 mg/mL (243.47 mM)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4347 mL	12.1737 mL	24.3475 mL	121.7374 mL
5 mM	0.4869 mL	2.4347 mL	4.8695 mL	24.3475 mL
10 mM	0.2435 mL	1.2174 mL	2.4347 mL	12.1737 mL
20 mM	0.1217 mL	0.6087 mL	1.2174 mL	6.0869 mL
50 mM	0.0487 mL	0.2435 mL	0.4869 mL	2.4347 mL
100 mM	0.0243 mL	0.1217 mL	0.2435 mL	1.2174 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc