Shopping Cart

Your shopping cart is currently empty

Squalene

Name: Squalene
Brand: TargetMol
SKU: T4749
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T4749Cas No. 111-02-4

Alias Super Squalene, AddaVax

Squalene (AddaVax) is an intermediate in cholesterol synthesis. Squalene has a variety of pharmacological properties, such as antilipemic, hepatoprotective, anti-atherosclerotic, cardioprotective, antioxidant, antitumor and antifungal.

Squalene

🥰Excellent

Purity: 99.33%

Catalog No. T4749Alias Super Squalene, AddaVaxCas No. 111-02-4

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$39	In Stock	In Stock
50 mg	$64	In Stock	In Stock
100 mg	$89	In Stock	In Stock
200 mg	$128	In Stock	In Stock
500 mg	$219	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.33%

Appearance:Liquid

Color:Transparent

Resource Download

COA HNMR GC

Product Introduction

Bioactivity

Description	Squalene (AddaVax) is an intermediate in cholesterol synthesis. Squalene has a variety of pharmacological properties, such as antilipemic, hepatoprotective, anti-atherosclerotic, cardioprotective, antioxidant, antitumor and antifungal.
Targets&IC50	HepG2 cells:100 μg/ml, JURKAT cells:26.22 μg/ml
In vitro	METHODS: Human MCF7, NCI-H460, and SF-268 cells were treated with Squalene (0-50 μM) for 72 hours, and MTS reduction assay was used to detect cell growth inhibition. RESULTS: Squalene did not inhibit the proliferation of MCF7, NCI-H460 and SF-268 cells (IC50>50 μM). [1] METHODS: MCF10A epithelial cells were treated with Squalene (12.5, 50, and 200 μM) for 24 hours, and ROS levels were measured using a microplate reader. RESULTS: Squalene reduced intracellular ROS levels. [2]
In vivo	METHODS: To study the effect of Squalene on lipid parameters, mice were fed a diet containing Squalene (0.25-1 g/kg) for 11 weeks. RESULTS: Squalene promoted the changes of HDL-cholesterol and paraoxonase 1, and decreased the reactive oxygen species in lipoproteins and plasma malondialdehyde levels. [3]
Synonyms	Super Squalene, AddaVax

Chemical Properties

Molecular Weight	410.72
Formula	C₃₀H₅₀
Cas No.	111-02-4
Smiles	CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C
Relative Density.	> 0.855 - < 0.865. Temperature:20 °C.

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 100 mg/mL (243.47 mM)

DMSO: 100 mg/mL (243.47 mM)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4347 mL	12.1737 mL	24.3475 mL	121.7374 mL
5 mM	0.4869 mL	2.4347 mL	4.8695 mL	24.3475 mL
10 mM	0.2435 mL	1.2174 mL	2.4347 mL	12.1737 mL
20 mM	0.1217 mL	0.6087 mL	1.2174 mL	6.0869 mL
50 mM	0.0487 mL	0.2435 mL	0.4869 mL	2.4347 mL
100 mM	0.0243 mL	0.1217 mL	0.2435 mL	1.2174 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc