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Solifenacin

Catalog No. T8147 CAS 242478-37-1

Synonyms: YM905 free base

Solifenacin (YM905 free base) (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0, respectively.

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Solifenacin, CAS 242478-37-1

Pack Size	Availability	Price/USD
10 mg	In stock	$ 39.00
25 mg	In stock	$ 65.00
50 mg	In stock	$ 97.00
100 mg	In stock	$ 155.00
200 mg	In stock	$ 228.00
500 mg	In stock	$ 369.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.91%

Biological Description

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Storage & Solubility Information

Description	Solifenacin (YM905 free base) (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0, respectively.
Targets&IC50	M1 receptor:7.6 (ki), M2 mAChR:6.9 (ki), M3 mAChR:8 (ki)
In vivo	Solifenacin exerts minimal inhibitory effects on salivary and cardiac responses at a dosage of 630 nmol/kg (0.3 mg/kg), achieving inhibition levels of 66% and 49%, respectively, at 2100 nmol/kg (1 mg/kg). At lower doses (63 and 210 nmol/kg or 0.03 and 0.1 mg/kg), Solifenacin slightly enhances saliva secretion. Conversely, it reduces bladder responses by 40% at 210 nmol/kg (0.1 mg/kg) and completely suppresses them at 2100 nmol/kg (1 mg/kg). Intravenously administered, Solifenacin (0.01 to 0.3 mg/kg) progressively augments bladder capacity and the volume of urine voided when dosed at 0.03 mg/kg or higher, without impacting residual volume or micturition pressure at any administered dosage.

Synonyms	YM905 free base
Molecular Weight	362.46
Formula	C23H26N2O2
CAS No.	242478-37-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 49 mg/mL (135.18 mM)

H2O: < 0.1 mg/mL (insoluble)

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Inhibitor Library Membrane Protein-targeted Compound Library Approved Drug Library ReFRAME Related Library Drug-induced Liver Injury (DILI) Compound Library FDA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Pseudotaraxasterol Cytisinicline Dipivefrin hydrochloride 9-CP-Ade Mesylate Promethazine N-0861 racemate ASM-024 Adiphenine hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Solifenacin 242478-37-1 Neuroscience AChR Muscarinic acetylcholine receptor YM905 mAChR YM 905 Inhibitor inhibit YM905 free base YM-905 inhibitor

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