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Sodium butanoate

Catalog No. T1393 CAS 156-54-7

Synonyms: Sodium Butyrate, Butanoic acid sodium salt

Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs).

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Sodium butanoate, CAS 156-54-7

Pack Size	Availability	Price/USD
200 mg	In stock	$ 40.00
250 mg	In stock	$ 43.00
500 mg	In stock	$ 50.00
1 g	In stock	$ 53.00

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Purity: 99.44%

Purity: 98.02%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Cell Research

Cells are seeded at a density of 2,000 cells/well in 96-well plates with 200 μL culture medium containing Sodium Butyrate at different concentrations. Then, the cells are consecutively cultured for 72 h. Every 24 h, 20 μL 5 mg/mL MTT solution is added into the corresponding well, and the cells are cultured for another 4 h. Then, the solution is replaced with 150 μL dimethylsulfoxide, followed by gentle agitation of the plates for 15 min at room temperature. Finally, the absorbance at 492 nm is measured to represent the cell viability.

Synonyms	Sodium Butyrate, Butanoic acid sodium salt
Molecular Weight	110.09
Formula	C4H7NaO2
CAS No.	156-54-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 33.3 mg/mL (30.27 mM), Need ultrasonic

H2O: 100 mg/mL (908.35 mM), need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Archer SY, et al. Proc Natl Acad Sci U S A, 1998, 95(12), 6791-6796. 2. Hague A, et al. Int J Cancer, 1993, 55(3), 498-505. 3. Hamer HM, et al. Aliment Pharmacol Ther, 2008, 27(2), 104-119. 4. Davie JR, et al. J Nutr, 2003, 133(7 Suppl), 2485S-2493S. 5. Ferrante RJ, et al. J Neurosci, 2003, 23(28), 9418-9427. 6. Jung HY, et al. Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation. Lab Anim Res. 2016 Dec;32(4):224-230 7. Huang W, et al. Inhibition of store-operated Ca2+ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate. Oncol Lett. 2017 Feb;13(2):921-929 8. Wang P, et al. Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition. Neurobiol Dis. 2017 Dec 14;111:12-25. 9. Jaworska J, et al. The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia. J Neuroinflammation. 2017 Feb 10;14(1):34 10. Qiu Y, et al. Effect of sodium butyrate on cell proliferation and cell cycle in porcine intestinal epithelial (IPEC-J2) cells. In Vitro Cell Dev Biol Anim. 2017 Jan 27

Related compound libraries

This product is contained In the following compound libraries：

Clinical Compound Library FDA-Approved & Pharmacopeia Drug Library Histone Modification Compound Library HIF-1 Signaling Pathway Compound Library Anti-Obesity Compound Library Anti-Cancer Drug Library Neurotransmitter Receptor Compound Library NO PAINS Compound Library Anti-Aging Compound Library Human Metabolite Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Sodium butanoate 156-54-7 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor Sodium Butyrate Butanoic acid sodium salt inhibitor inhibit

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