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Sodium butanoate

Sodium butanoate
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Purity:99.44%
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Sodium butanoate

Catalog No. T1393Cas No. 156-54-7
Sodium butanoate (Sodium Butyrate) is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs).
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Pack SizePrice/USDAvailabilityQuantity
200 mg$40In Stock
250 mg$43In Stock
500 mg$50In Stock
1 g$53In Stock
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Product Introduction

Bioactivity
Description
Sodium butanoate (Sodium Butyrate) is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs).
In vitro
Sodium butyrate enhances the acetylation of histones and specific protein-1 while concurrently inhibiting the neurotoxicity induced by 3-nitropropionic acid. In the R6/2 transgenic mouse model of Huntington's disease, sodium butyrate effectively delays the onset of symptoms and prolongs the survival period.
In vivo
Sodium butyrate exhibits anti-inflammatory and anticancer effects in the colonic mucosa, reducing oxidative stress and thus inhibiting the growth of colon cancer cells. It also induces apoptosis in the RG/C2 and AA/Cl adenoma cell lines.
Cell Research
Cells are seeded at a density of 2,000 cells/well in 96-well plates with 200 μL culture medium containing Sodium Butyrate at different concentrations. Then, the cells are consecutively cultured for 72 h. Every 24 h, 20 μL 5 mg/mL MTT solution is added into the corresponding well, and the cells are cultured for another 4 h. Then, the solution is replaced with 150 μL dimethylsulfoxide, followed by gentle agitation of the plates for 15 min at room temperature. Finally, the absorbance at 492 nm is measured to represent the cell viability.
AliasSodium Butyrate, Butanoic acid sodium salt
Chemical Properties
Molecular Weight110.09
FormulaC4H7NaO2
Cas No.156-54-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 1.1 mg/mL (10 mM)
H2O: 100 mg/mL (908.35 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM9.0835 mL45.4174 mL90.8348 mL454.1739 mL
5 mM1.8167 mL9.0835 mL18.1670 mL90.8348 mL
H2O
1mg5mg10mg50mg
10 mM0.9083 mL4.5417 mL9.0835 mL45.4174 mL
20 mM0.4542 mL2.2709 mL4.5417 mL22.7087 mL
50 mM0.1817 mL0.9083 mL1.8167 mL9.0835 mL
100 mM0.0908 mL0.4542 mL0.9083 mL4.5417 mL

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