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Sodium benzoate

Catalog No. T8124 CAS 532-32-1

Synonyms: Benzoic acid sodium salt

Sodium benzoate (Benzoic acid sodium salt) is a D-Amino Acid Oxidase Inhibitor.Sodium Benzoate is a Food Preservative.

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Sodium benzoate, CAS 532-32-1

Pack Size	Availability	Price/USD
50 mg	In stock	$ 48.00
100 mg	In stock	$ 80.00
500 mg	In stock	$ 195.00
1 mL * 10 mM (in DMSO)	In stock	$ 38.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sodium benzoate (Benzoic acid sodium salt) is a D-Amino Acid Oxidase Inhibitor.Sodium Benzoate is a Food Preservative.
In vitro	At 24- and 48-hour. incubation time, sodium benzoate concentrations of 1.0, 1.5, and 2.0 mg/mL increased micronucleus formation when comparing with the control group (P < 0.05). At 24- and 48-hour. incubation time, sodium benzoate concentrations of 2.0 mg/mL increased chromosome break when comparing with the control group (P < 0.05). Sodium benzoate did not cause Ala40Thr (GCG→ACG) in superoxide dismutase gene. Sodium benzoate had the mutagenic and cytotoxic toxicity in lymphocytes caused by micronucleus formation and chromosome break[1].
In vivo	Sodium benzoate (NaB)?-treated rats spent less time in the open arm and had fewer entrances to the open arms in comparison with the control group (p<0.04). Also, the performance of the NaB-treated rats in fixed and accelerating speed rotarods was impaired, and the riding time (endurance) was lower than the control group (p<0.01)[2].
Animal Research	The study was carried out between July and September 2012 in the Laboratory Animal Center of Shiraz University of Medical Sciences, Shiraz, Iran. The rats were divided into 2 groups receiving distilled water and sodium benzoate (NaB)? (200mg/kg/day). All the animals received daily gavages for 4 weeks. At the end of the fourth week, anxiety, and motor function were assessed in elevated plus maze and rotarod test[2]

Synonyms	Benzoic acid sodium salt
Molecular Weight	144.1
Formula	C7H5NaO2
CAS No.	532-32-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.85 mg/mL (26.69 mM), Sonication is recommended.

H2O: 28 mg/mL (194.31 mM)

References and Literature

1. Malinee P . Effect of Sodium Benzoate Preservative on Micronucleus Induction, Chromosome Break, and Ala40Thr Superoxide Dismutase Gene Mutation in Lymphocytes[J]. Biomed Research International, 2015, 2015:1-5. 2. Noorafshan A , Erfanizadeh M , Karbalaydoust S . Sodium benzoate, a food preservative, induces anxiety and motor impairment in rats.[J]. Neurosciences, 2014, 19(19):24-28. 3. Lin C H , Lin C H , Chang Y C , et al. Sodium Benzoate, a D-amino Acid Oxidase Inhibitor, Added to Clozapine for the Treatment of Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial[J]. Biological Psychiatry, 2017:S0006322317322977.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Food Additive Library Approved Drug Library Bioactive Compound Library Bioactive Compounds Library Max Human Metabolite Library NO PAINS Compound Library Inactive Ingredient Library FDA-Approved Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Sodium benzoate 532-32-1 Others Benzoic acid sodium Sodium Benzoate Benzoic acid sodium salt inhibitor inhibit

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