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STO-609

Catalog No. T3546 CAS 52029-86-4

Synonyms: STO 609

STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/mL).

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STO-609, CAS 52029-86-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
5 mg	In stock	$ 113.00
10 mg	In stock	$ 183.00
25 mg	In stock	$ 387.00
50 mg	In stock	$ 565.00
100 mg	In stock	$ 788.00
500 mg	In stock	$ 1,620.00
1 mL * 10 mM (in DMSO)	In stock	$ 138.00

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Purity: 98.95%

Purity: 97.79%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/mL).
Targets&IC50	CaM-KKα:0.25 μM(Ki), CaM-KKβ:47 nM(Ki)
In vitro	STO-609 also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV), and the IC50 value of the compound against CaM-KII is 10 μg/mL. STO-609 inhibits constitutively active CaM-KKα as well as the wild-type enzyme. In transfected HeLa cells, STO-609 dose-dependently suppresses the Ca2+-induced activation of CaM-KIV. STO-609 (1μg/mL) significantly reduces the endogenous activity of CaM-KK in SH-SY5Y neuroblastoma cells (80%).

Synonyms	STO 609
Molecular Weight	314.29
Formula	C19H10N2O3
CAS No.	52029-86-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.17 mg/mL (13.26 mM), Sonication is recommended.

References and Literature

1. Tokumitsu H,rt al. STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002 May 3;277(18):15813-8. Epub 2002 Feb 26. 2. Kukimoto-Niino M,et al. Crystal structure of the Ca²⁺/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem. 2011 Jun 24;286(25):22570-9. 3. Kan J, Zhao C, Lu S, et al. S100A16, a novel lipogenesis promoting factor in livers of mice and hepatocytes in vitro[J]. Journal of cellular physiology. 2019 May 8.

Citations

1. Kan J, Zhao C, Lu S, et al. S100A16, a novel lipogenesis promoting factor in livers of mice and hepatocytes in vitro. Journal of Cellular Physiology. 2019 May 8 2. Xu J, Xu X, Ling Y, et al.Vincamine as an agonist of G-protein-coupled receptor 40 effectively ameliorates diabetic peripheral neuropathy in mice.Acta Pharmacologica Sinica.2023: 1-16.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library PI3K-AKT-mTOR Compound Library AMPK-Targeted Compound Library Anti-Lung Cancer Compound Library Neuronal Signaling Compound Library Anti-Breast Cancer Compound Library Autophagy Compound Library Epigenetics Compound Library Antidepressant Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

STO-609 52029-86-4 Autophagy Chromatin/Epigenetic Neuroscience PI3K/Akt/mTOR signaling CaMK AMPK AMP-activated protein kinase STO609 Calmodulin-dependent protein kinases STO 609 Inhibitor Calmodulin-dependent kinases inhibit inhibitor

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