Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 219.00 | |
5 mg | In stock | $ 478.00 | |
10 mg | In stock | $ 787.00 | |
25 mg | In stock | $ 1,190.00 | |
50 mg | In stock | $ 1,630.00 | |
100 mg | In stock | $ 2,180.00 | |
500 mg | In stock | $ 4,390.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 528.00 |
Description | SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1. |
Targets&IC50 | COX-2:26 nM |
In vitro | SC57666 exhibits potent inhibition of COX2 (IC50 of 3.2±0.8 nM) in CHO cells stably transfected with human COX isozymes, showing a selectivity of 1000-fold or greater over COX1 (IC50=6000±1900 nM) [1]. |
In vivo | In the adjuvant-induced arthritis model, SC57666 exhibits oral activity with an ED50 of 1.7 mpk. When administered orally at a dose of 600 mpk, SC57666 does not cause gastric lesions in mice after 5 hours. Similarly, no intestinal damage is observed in rats after 72 hours when administered orally at a dose of 200 mpk [2]. |
Molecular Weight | 316.39 |
Formula | C18H17FO2S |
CAS No. | 158959-32-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (284.5 mM)
You can also refer to dose conversion for different animals. More
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SC57666 158959-32-1 Immunology/Inflammation Neuroscience COX SC 57666 SC-57666 inhibitor inhibit