Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, <130-fold selectivity for JAK1/2 versus JAK3.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 44.00 | |
10 mg | In stock | $ 59.00 | |
25 mg | In stock | $ 75.00 | |
50 mg | In stock | $ 98.00 | |
100 mg | In stock | $ 148.00 | |
200 mg | In stock | $ 239.00 | |
500 mg | In stock | $ 439.00 | |
1 g | In stock | $ 648.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 54.00 |
Description | Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. |
Targets&IC50 | JAK2:2.8 nM, JAK1:3.3 nM |
In vitro | Ruxolitinib (INCB018424) potently and selectively inhibits JAK2V617F-mediated signaling and proliferation. Ruxolitinib inhibits the growth of HEL cells with EC50 of 186 nM. Ruxolitinib markedly increases apoptosis in Ba/F3-EpoR-JAK2V617F cell system. It also inhibits hematopoietic progenitor cell proliferation in primary MPN patient samples[1]. |
In vivo | Ruxolitinib (180 mg/kg, p.o.) reduces the tumor burden of mice inoculated with JAK2V617F-expressing cells while not causing anemia or lymphopenia[1]. |
Cell Research | Ruxolitinib phosphate is dissolved in 0.2% DMSO. Cells are seeded at 2000/well of white bottom 96-well plates, treated with compounds from DMSO stocks (0.2% final DMSO concentration), and incubated for 48 hours at 37°C with 5% CO2. Viability is measured by cellular ATP determination using the Cell-Titer Glo luciferase reagent or viable cell counting. Values are transformed to percent inhibition relative to vehicle control, and IC50?curves are fitted according to nonlinear regression analysis of the data using PRISM GraphPad. |
Synonyms | INC424, INCB018424, INC 424 phosphate, Ruxolitinib (INCB-18424) phosphate, INCB018424 phosphate |
Molecular Weight | 404.36 |
Formula | C17H21N6O4P |
CAS No. | 1092939-17-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 70 mg/mL(173.1 mM)
H2O: 8 mg/mL(19.8 mM)
You can also refer to dose conversion for different animals. More
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Ruxolitinib phosphate 1092939-17-7 Angiogenesis Autophagy Chromatin/Epigenetic JAK/STAT signaling Stem Cells Mitophagy JAK Ruxolitinib inhibit INCB 018424 Phosphate INCB 018424 INCB-018424 INC424 INC424 Phosphate Mitochondrial Autophagy Ruxolitinib Phosphate INCB018424 INC 424 phosphate INC 424 INC-424 Phosphate Inhibitor INC 424 Phosphate INCB-018424 Phosphate INCB018424 Phosphate Ruxolitinib (INCB-18424) phosphate INCB018424 phosphate Ruxolitinib (INCB-18424) Phosphate INC-424 Janus kinase inhibitor