Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RCM-1 is an inhibitor of FOXM1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
5 mg | In stock | $ 82.00 | |
10 mg | In stock | $ 141.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 491.00 | |
100 mg | In stock | $ 716.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 91.00 |
Description | RCM-1 is an inhibitor of FOXM1. |
In vitro | RCM-1 inhibits cellular proliferation via the increasing duration of cell cycle and mitosis in human and mouse cancer cell lines in vitro. RCM-1 inhibits colony formation of cancer cells in vitro in a dose-dependent manner. RCM-1 inhibits the migration of cancer cells in vitro in a dose-dependent manner. RCM-1 inhibits the initiation as well as the growth of cancer cell colonies in vitro. Treatment with RCM-1 increases the duration of mitosis and cell cycle in the cancer cell lines [1]. |
In vivo | RCM-1 decreases the B 16-FlO tumor growth as compared to the Vehicle -treated group. RCM-1 treatment decreases tumor cell proliferation and increased apoptosis in B16-FlO melanoma tumors. RCM-1 treatment reduces the growth of the human H2122 lung adenocarcinoma in mice. RCM-1 treatment reduces tumor cell proliferation and increases apoptosis in Rd76-9 rhabdomyosarcoma tumors. RCM-1 treatment decreases the growth of Rd76-9 rhabdomyosarcomas in mice. The RCM-1-treated Rd76-9 tumors display reduced FOXM1 staining and decreased expression of proliferation-specific markers Ki67 and PH3. Cleaved caspase staining is increased in the RCM-1 treated tumors, indicating an increase in apoptosis. RCM-1 treatment reduces the growth of B16-FlO melanoma tumors in mice [1]. |
Molecular Weight | 424.58 |
Formula | C20H12N2OS4 |
CAS No. | 339163-65-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (39.26 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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RCM-1 339163-65-4 Others Inhibitor RCM 1 inhibit RCM1 inhibitor