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Quinine sulfate dihydrate

Catalog No. TN4883 CAS 6119-70-6

Quinine sulfate dihydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassium channel. It is also used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

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Quinine sulfate dihydrate Chemical Structure

Quinine sulfate dihydrate, CAS 6119-70-6

Pack Size	Availability	Price/USD	Quantity
10 g	In stock	$ 29.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.85%

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Description	Quinine sulfate dihydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassium channel. It is also used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.
Targets&IC50	P. falciparum (60 Thai isolates):10 to 500 nM (MIC)
In vitro	Quinine is an alkaloid antimalarial agent that has MIC values ranging from 10 to 500 nM for 60 Thai isolates of P. falciparum. It inhibits hemozoin formation in purified trophozoites, leading to an increase in free heme, similar to the mechanism of action of chloroquine[1].
In vivo	In mice, quinine reduces P. berghei parasite load in the blood with a minimum effective dose (MED) of 150 mg/kg [2].

Molecular Weight	818.97
Formula	C40H58N4O12S
CAS No.	6119-70-6

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 8.19 mg/mL (10 mM)

References and Literature

1. Thaithong S, et al. Susceptibility of Plasmodium falciparum to five drugs: an in vitro study of isolates mainly from Thailand. Trans R Soc Trop Med Hyg. 1983;77(2):228-31. 2. THURSTON JP. The action of antimalarial drugs in mice infected with Plasmodium berghei. Br J Pharmacol Chemother. 1950 Sep;5(3):409-16.

Related compound libraries

This product is contained In the following compound libraries：

Antiparasitic Natural Product Library Anti-Parasitic Compound Library Alkaloid Natural Product Library Natural Product Library for HTS Bioactive Compounds Library Max Mitochondria-Targeted Compound Library Traditional Chinese Medicine Monomer Library Selected Plant-Sourced Compound Library Bioactive Compound Library

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Quinine sulfate dihydrate 6119-70-6 Others Quinine sulfate Dihydrate Quinine Sulfate inhibitor inhibit

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