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Prunin

Catalog No. TN2111 CAS 529-55-5

Synonyms: Naringenin 7-0-glucoside

Prunin (Naringenin 7-0-glucoside) possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can stimulate growth of Pseudomonas aeruginosa and different Bacilllus sp. Prunin exhibits a markedly enhanced solubility compared to naringenin and naringin while maintaining the in vitro inhibition of HMG-CoA reductase.

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Prunin, CAS 529-55-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 128.00
5 mg	In stock	$ 277.00
10 mg	In stock	$ 473.00
25 mg	In stock	$ 759.00
50 mg	In stock	$ 987.00
100 mg	In stock	$ 1,380.00
500 mg	In stock	$ 2,790.00
1 mL * 10 mM (in DMSO)	In stock	$ 323.00

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Purity: 99.52%

Purity: 99.02%

Biological Description

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Storage & Solubility Information

Description	Prunin (Naringenin 7-0-glucoside) possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can stimulate growth of Pseudomonas aeruginosa and different Bacilllus sp. Prunin exhibits a markedly enhanced solubility compared to naringenin and naringin while maintaining the in vitro inhibition of HMG-CoA reductase.
In vitro	The effects of Prunin- and HG-alkyl (C4-C18) esters (0.1-100μM) on human leukemia T (Jurkat) cells viability and plasma membrane fluidity were evaluated. At this concentration, cell hyperpolarization and shrinkage were also observed. Cell plasma membrane fluidity was not affected, regardless the depths of the membrane level evaluated, but mild changes in plasma membrane hydration were found. Esterification did not affect the antioxidant capacity of Prunin and HG (0.1-10μM) against 1mM H2O2. When exposed to 1mM AAPH, P-alkyl esters retained Prunin antioxidant capacity, but HG-derivatives acted as pro-oxidants[1]
Source	Natural Products > Podocarpaceae > Podocarpus

Synonyms	Naringenin 7-0-glucoside
Molecular Weight	434.39
Formula	C21H22O10
CAS No.	529-55-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (57.55 mM)

References and Literature

1. Prunin- and hesperetin glucoside-alkyl (C4-C18) esters interaction with Jurkat cells plasma membrane: consequences on membrane physical properties and antioxidant capacity.Food Chem Toxicol. 2013 May;55:411-23.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Inhibitor Library Miao medicine Compound Library Anti-Infection Compound Library Covalent Inhibitor Library Anti-Viral Compound Library Phosphatase Inhibitor Library Metabolism Compound Library Natural Product Library for HTS Anti-virus Traditional Chinese Medicine Monomer Library

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Keywords

Prunin 529-55-5 Metabolism Microbiology/Virology Anti-infection Phosphatase Virus Protease HEVs HEV RNA HRVs Inhibitor infection Enterovirus inhibit Naringenin 7-0-glucoside synthesis anti-diabetic Rhinovirus HRV inhibitor

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