Home Tools

Procaine hydrochloride

Catalog No. T0802 CAS 51-05-8

Synonyms: Novocaine HCl, Procaine HCl

Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Procaine hydrochloride Chemical Structure

Procaine hydrochloride, CAS 51-05-8

Pack Size	Availability	Price/USD
500 mg	In stock	$ 42.00
1 g	In stock	$ 50.00
5 g	In stock	$ 79.00

Bulk Inquiry

Select Batch

Purity: 99%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
Targets&IC50	NMDAR:0.296 mM, Na+ channel:60 μM, nAChR:45.5 μM, 5-HT3:1.7 μM(Kd)
In vitro	In anesthetized cats, Procaine (15 mg/kg) enhanced the cellular activity in the ventral hippocampal formation of the amygdala, the ventromedial hypothalamus, the septal nucleus, and the neocortex of the temporal lobe. Procaine acts as a stimulant for marginal system cells. Furthermore, Procaine facilitates the conduction of evoked stimulatory activity from the amygdala to the ventromedial hypothalamus.
In vivo	Procaine exhibits the ability to bind to or antagonize nicotinic acetylcholine receptors and the 5-HT(serotonin) receptor-ion channel complex, as well as N-methyl-D-aspartate (NMDA) receptors. Its primary mechanism of action involves the inhibition of sodium ion influx by affecting the voltage-gated sodium channels on the neuronal cell membranes of peripheral nerves. This disruption of sodium ion flow prevents the generation of action potentials, thereby inhibiting signal transduction. Studies suggest that the receptor sites targeted by procaine are located on the cytoplasmic (internal) portion of the sodium channels.

Synonyms	Novocaine HCl, Procaine HCl
Molecular Weight	272.77
Formula	C13H20N2O2·HCl
CAS No.	51-05-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 51 mg/mL (187 mM)

H2O: 50 mg/mL (183.3 mM)

References and Literature

1. Bräu ME ME, et al. Anesth Analg, 1998, 87(4), 885-889. 2. Hahnenkamp K, et al. Br J Anaesth, 2006, 96(1), 77-87. 3. Wang H, et al. Eur J Pharmacol, 2010, 630(1-3), 29-33. 4. Fan P, et al. Neuropharmacology, 1994, 33(12), 1573-1579. 5. Zahradníková A, et al. Biophys J. 1993 Apr;64(4):1991-12003.

Related compound libraries

This product is contained In the following compound libraries：

Antidepressant Compound Library Anti-Infection Compound Library Anti-Viral Compound Library FDA-Approved & Pharmacopeia Drug Library DNA Damage & Repair Compound Library Histone Modification Compound Library Serotonin Receptor-Targeted Compound Library NO PAINS Compound Library Anti-Cancer Compound Library Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

GSK J5 CPI-455 HCl LSD1-IN-5 ML324 PBIT KDM2A/7A-IN-1 5-Hydroxy-7-acetoxy-8-methoxyflavone IOX1

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Procaine hydrochloride 51-05-8 Cell Cycle/Checkpoint Chromatin/Epigenetic DNA Damage/DNA Repair GPCR/G Protein Membrane transporter/Ion channel Neuroscience Histone Demethylase 5-HT Receptor DNA/RNA Synthesis Sodium Channel NMDAR AChR Procaine Hydrochloride onset Procaine Inhibitor targets inhibit multiple Novocaine HCl Procaine HCl duration inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.