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Poricoic acid B

Catalog No. TN1031 CAS 137551-39-4

Poricoic acid B shows inhibitory activity against TPA-induced ear inflammatory oedema, it also shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).

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Poricoic acid B, CAS 137551-39-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 72.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 297.00
25 mg	In stock	$ 492.00
50 mg	In stock	$ 718.00
100 mg	In stock	$ 987.00
1 mL * 10 mM (in DMSO)	In stock	$ 228.00

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Purity: 98.99%

Purity: 98.93%

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Description	Poricoic acid B shows inhibitory activity against TPA-induced ear inflammatory oedema, it also shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).
In vitro	These two, and eight other known compounds isolated from the sclerotium, Poricoic acid B (3), poricoic acid A (4), tumulosic acid (5), dehydrotumulosic acid (6), 3-epidehydrotumulosic acid (7), polyporenic acid C (8), 25-hydroxy-3-epidehydrotumulosic acid (9), and dehydroabietic acid methyl ester (10), showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Evaluation of the cytotoxicity of compounds 1 and 4 against human cancer cell lines revealed that 1 was significantly cytotoxic to leukemia HL-60 cells [GI(50) (concentration that yields 50% growth) value 39.3 nM], although it showed only moderate cytotoxicity to the other cells. Compound 4 exhibited moderate cytotoxicity to all of the cancer cell lines tested.
Source	Natural Products > Polyporaceae > Wolfiporia

Molecular Weight	484.67
Formula	C30H44O5
CAS No.	137551-39-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (46.42 mM)

References and Literature

1. Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.J Nat Prod. 2002 Apr;65(4):462-5.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Anti-Cancer Active Compound Library Anti-Tumor Natural Product Library Anti-infective Natural Product Library Bioactive Compound Library Bioactive Compounds Library Max Food as Medicine Compound Library Anti-virus Traditional Chinese Medicine Monomer Library Natural Product Library for HTS Selected Plant-Sourced Compound Library

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Keywords

Poricoic acid B 137551-39-4 Others Inhibitor inhibit inhibitor

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