Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pirmitegravir (STP0404) is a potent and selective inhibitor of allosteric integrase (ALLINI) targeting the LEDGF/p75 binding site. Pirmitegravir inhibits PBMC. Pirmitegravir inhibits PBMC.Pirmitegravir has significant antiviral activity and may be useful in the study of HIV virus infection.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 350.00 | |
5 mg | In stock | $ 970.00 | |
10 mg | In stock | $ 1,830.00 | |
25 mg | In stock | $ 2,270.00 | |
50 mg | In stock | $ 3,110.00 | |
100 mg | In stock | $ 4,670.00 |
Description | Pirmitegravir (STP0404) is a potent and selective inhibitor of allosteric integrase (ALLINI) targeting the LEDGF/p75 binding site. Pirmitegravir inhibits PBMC. Pirmitegravir inhibits PBMC.Pirmitegravir has significant antiviral activity and may be useful in the study of HIV virus infection. |
Targets&IC50 | HIV-1:0.41 nM, CEMx174 cells:1.4 nM |
In vitro |
In CEMx174 cells, Pirmitegravir demonstrates an IC50 of 1.4 nM, inhibiting dual tropic HIV-189.6[1]. Pirmitegravir is a highly potent ALLINI, inhibiting both wild-type and Ral-resistant HIV-1 strains, with IC50 values ranging from picomolar to single-digit nanomolar[1].With an IC50 of 0.41 nM against HIV-1NL4-3, Pirmitegravir exhibits no observable cytotoxicity in human PBMCs at 10 μM (TC50 >10μM)[1]. |
In vivo |
For once-daily administration, Pirmitegravir exhibits appropriate PK profiles[1]. The lack of micronucleus-inducing and bone marrow cell proliferation inhibitory potentials in rats (500, 1000, and 2000 mg/kg/day) supports the conclusion that Pirmitegravir is not genotoxic[1].An assessment of the Pharmacokinetics (PK) profile of Pirmitegravir in rat and dog has been conducted[1]. |
Synonyms | STP0404 |
Molecular Weight | 495.01 |
Formula | C27H31ClN4O3 |
CAS No. | 2245231-10-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (111.11 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Pirmitegravir 2245231-10-9 Microbiology/Virology Proteases/Proteasome HIV Protease STP0404 inhibitor inhibit