Powder: -20°C for 3 years
In solvent: -80°C for 2 years
PP58 is an inhibitor of PDGFR, FGFR and Src family.
Description | PP58 is an inhibitor of PDGFR, FGFR and Src family. |
In vitro | PP58 inhibits anisomycin-activated p38 in a dose-dependent manner with an IC50 < 10 nM. LPS-stimulated TNF-α production is potently inhibited by PP58 with a cellular IC50 value of 3 nM[1]. |
In vivo | PP58 exhibits some degree of selectivity in vivo[1]. |
Molecular Weight | 456.33 |
Formula | C22H19Cl2N5O2 |
CAS No. | 212391-58-7 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 56.3mg/mL (123.3mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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PP58 212391-58-7 Angiogenesis Apoptosis MAPK Tyrosine Kinase/Adaptors PDGFR TNF FGFR Src p38 MAPK PP-58 Inhibitor inhibitor inhibit