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Ombuin

Catalog No. TN2010 CAS 529-40-8

Ombuin has anti-inflammatory activity, it inhibits some macrophage functions involved in the inflammatory process.

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Ombuin, CAS 529-40-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
5 mg	In stock	$ 249.00
10 mg	In stock	$ 369.00
1 mL * 10 mM (in DMSO)	In stock	$ 470.00

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Purity: 99.71%

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Description	Ombuin has anti-inflammatory activity, it inhibits some macrophage functions involved in the inflammatory process.
Targets&IC50	Antibacterial:125- 500 μg/mL(MIC)
In vitro	Compounds 1-7 were evaluated as inhibitors of some macrophage functions involved in the inflammatory process. These seven compounds significantly and dose-dependently inhibited lipopolysaccharide (LPS) and interferon (IFN)-gamma induced nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. The concentration causing a 50% inhibition (IC50) of NO, TNF-alpha and IL-12 production by compounds 1, 2 and 7 was approximately 30, 50 and 10 microM, respectively, while at 50, 200 and 40 microM compounds 3, 4, and 5, 6 showed 15-30% inhibition, respectively. On the other hand, compounds 3 and 7 showed no inhibitory effect, while compounds 1, 4-6 reduced by around 10-30% the synthesis of NO by macrophages, when inducible NO synthase was already expressed with LPS/IFN-gamma for 24 h[1]
Source	Natural Products > Fabaceae > Caesalpinia

Molecular Weight	330.29
Formula	C17H14O7
CAS No.	529-40-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (181.66 mM)

References and Literature

1. Antiinflammatory activities of flavonoids and a triterpene caffeate isolated from Bauhinia variegata.Phytother Res. 2008 Jul;22(7):957-62.

Related compound libraries

This product is contained In the following compound libraries：

RO5 Drug-like Natural Product Library Flavonoid Natural Product Library Rare Natural Compound Library

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Keywords

Ombuin 529-40-8 Microbiology/Virology Antibacterial armatum Inhibitor spectrum Bacterial broad antibacterial inhibit Zanthoxylum inhibitor

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