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Neoechinulin A

Catalog No. TN4635   CAS 51551-29-2

Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits, it has a potential to be developed as a modulator of neuroinflammatory process in Alzheimer's disease. Neoechinulin A may ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities.

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Neoechinulin A Chemical Structure
Neoechinulin A, CAS 51551-29-2
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1 mL * 10 mM (in DMSO) Inquiry $ 630.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits, it has a potential to be developed as a modulator of neuroinflammatory process in Alzheimer's disease. Neoechinulin A may ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities.
Molecular Weight 323.39
Formula C19H21N3O2
CAS No. 51551-29-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

Neoechinulin A 51551-29-2 Apoptosis GPCR/G Protein Immunology/Inflammation MAPK Neuroscience NF-Κb IκB/IKK ASK Beta Amyloid NADPH-oxidase TNF p38 MAPK NOS NF-κB Prostaglandin Receptor COX inhibitor inhibit

 

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