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NVR 3-778

Catalog No. T16366 CAS 1445790-55-5

NVR 3-778 is a first-in-Class and oral bioavailable HBV CAM belonging to the SBA class It has anti-HBV activity.

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NVR 3-778, CAS 1445790-55-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 189.00
25 mg	In stock	$ 372.00
50 mg	In stock	$ 563.00
100 mg	In stock	$ 812.00
1 mL * 10 mM (in DMSO)	In stock	$ 133.00

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Purity: 99.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NVR 3-778 is a first-in-Class and oral bioavailable HBV CAM belonging to the SBA class It has anti-HBV activity.
In vitro	NVR 3-778 inhibits the generation of infectious HBV DNA-containing virus particles with a mean antiviral (EC50: 0.40?μM in HepG2.2.15 cells). NVR 3-778 inhibits pregenomic RNA encapsidation, viral replication, and the production of HBV DNA- and HBV RNA-containing particles. NVR 3-778 also inhibits de novo infection and viral replication in primary human hepatocytes with EC50s of 0.81?μM against HBV DNA and between 3.7μM and 4.8?μM against the production of HBV antigens and intracellular HBV RNA. NVR 3-778 targets HBV core protein and inhibits viral replication. NVR 3-778 has pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication. The EC50 values of NVR 3-778 are increased by 4.5-, 9.3-, and 15.8-fold in the presence of 10%, 20%, and 40% human serum, respectively.
In vivo	In dogs following oral administration, NVR 3-778 (1.5?mg/kg; i.g.) shows the mean Cmax and AUC0–inf values of 0.56?μg/ml and 3.50?μg·h/ml, respectively. And the mean oral bioavailability is determined to be 84.6%.

Molecular Weight	432.39
Formula	C18H16F4N2O4S
CAS No.	1445790-55-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (138.76 mM)

References and Literature

1. Lam AM, et al. Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus. Antimicrob Agents Chemother. 2018 Dec 21;63(1).

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library NO PAINS Compound Library Bioactive Compound Library ReFRAME Related Library Anti-Infection Compound Library Anti-Viral Compound Library Orally Active Compound Library Bioactive Compounds Library Max Clinical Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NVR 3-778 1445790-55-5 Microbiology/Virology HBV virus assembly CAM modulator inhibit NVR 3 778 capsid Hepatitis chronic Hepatitis B virus Inhibitor NVR 3778 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.