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NVR 3-778

Catalog No. T16366   CAS 1445790-55-5

NVR 3-778 is a first-in-Class and oral bioavailable HBV CAM belonging to the SBA class It has anti-HBV activity.

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NVR 3-778, CAS 1445790-55-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 51.00
5 mg In stock $ 122.00
10 mg In stock $ 189.00
25 mg In stock $ 372.00
50 mg In stock $ 563.00
100 mg In stock $ 812.00
1 mL * 10 mM (in DMSO) In stock $ 133.00
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Purity: 99.87%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description NVR 3-778 is a first-in-Class and oral bioavailable HBV CAM belonging to the SBA class It has anti-HBV activity.
In vitro NVR 3-778 inhibits the generation of infectious HBV DNA-containing virus particles with a mean antiviral (EC50: 0.40?μM in HepG2.2.15 cells). NVR 3-778 inhibits pregenomic RNA encapsidation, viral replication, and the production of HBV DNA- and HBV RNA-containing particles. NVR 3-778 also inhibits de novo infection and viral replication in primary human hepatocytes with EC50s of 0.81?μM against HBV DNA and between 3.7μM and 4.8?μM against the production of HBV antigens and intracellular HBV RNA. NVR 3-778 targets HBV core protein and inhibits viral replication. NVR 3-778 has pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication. The EC50 values of NVR 3-778 are increased by 4.5-, 9.3-, and 15.8-fold in the presence of 10%, 20%, and 40% human serum, respectively.
In vivo In dogs following oral administration, NVR 3-778 (1.5?mg/kg; i.g.) shows the mean Cmax and AUC0–inf values of 0.56?μg/ml and 3.50?μg·h/ml, respectively. And the mean oral bioavailability is determined to be 84.6%.
Molecular Weight 432.39
Formula C18H16F4N2O4S
CAS No. 1445790-55-5


Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 60 mg/mL (138.76 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Lam AM, et al. Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus. Antimicrob Agents Chemother. 2018 Dec 21;63(1).

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max NO PAINS Compound Library Anti-Viral Compound Library Anti-Infection Compound Library Orally Active Compound Library Clinical Compound Library ReFRAME Related Library Drug Repurposing Compound Library Bioactive Compound Library

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NVR 3-778 1445790-55-5 Microbiology/Virology HBV virus assembly CAM modulator inhibit NVR 3 778 capsid Hepatitis chronic Hepatitis B virus Inhibitor NVR 3778 inhibitor