Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Monepantel is an organic anthelmintic. Monepantel is also used for a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 89.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 413.00 | |
25 mg | In stock | $ 828.00 | |
50 mg | In stock | $ 1,230.00 | |
100 mg | In stock | $ 1,670.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 293.00 |
Description | Monepantel is an organic anthelmintic. Monepantel is also used for a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits. |
In vitro | Monepantel (0, 10 and 25 μM) decreases autophagosome formation in these cancer cell lines. Monepantel also decreases the expression of phosphorylated Raptor at Ser792, which is one of the mTORC1 coMonepantelex members[2]. Monepantel (0, 10 and 25 μM) shows a markedly reduced level of punctate staining indicating the suppression of phosphorylated mTOR at Ser2448. Monepantel (250 μg/mL) leads multiple ABC transporter genes higher transcription in both worm isolates. The metallocenyl analogues of monepantel displays nematocidal activity[1]. Monepantel (25 μM) induces the accumulation of acidic vacuoles. Ovarian cancer cell lines are highly sensitive to Monepantel (IC50: 7.2±0.2 μM (OVCAR-3) and 10.5±0.4 μM (A2780)). Larvae exposed to monepantel at 250 μg/mL shows an increased efflux of rhodamine-123. A proportion of the larval population shows an ability to subsequently tolerate higher concentrations of IVM in migration assays[3]. |
In vivo | Monepantel (10 μM) obviously enhanced all CYP-related activities and CYP3A24 mRNA in sheep[4]. |
Synonyms | AAD1566 |
Molecular Weight | 473.39 |
Formula | C20H13F6N3O2S |
CAS No. | 887148-69-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (211.24 mM)
You can also refer to dose conversion for different animals. More
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Monepantel 887148-69-8 Others AAD-1566 AAD 1566 AAD1566 inhibitor inhibit