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Methocarbamol

Catalog No. T1409 CAS 532-03-6

Synonyms: Lumirelax, AHR 85, Robaxin, Metocarbamol

Methocarbamol is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm.

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Methocarbamol, CAS 532-03-6

Pack Size	Availability	Price/USD
25 mg	In stock	$ 38.00
50 mg	In stock	$ 50.00
100 mg	In stock	$ 63.00
200 mg	In stock	$ 75.00
500 mg	In stock	$ 88.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.75%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Methocarbamol is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm.
In vitro	Methocarbamol is metabolized via dealkylation and hydroxylation followed by conjugation to form both glucuronides and sulfates. [1]
In vivo	Methocarbamol results in a median terminal half-life, mean transit time, mean absorption time, and apparent oral clearance of 2.89 hours, 2.67 hours, 0.410 hours, and 16.5 mL/min/kg in the horse. Methocarbamol is rapidly absorbed and extensively metabolized after oral administration to horses as indicated by a short absorption time and modest systemic bioavailability of 54.4% in the horse. [1] Methocarbamol is a centrally acting muscle relaxant available in both IV and oral forms in cats. [2] Methocarbamol (100 mg/kg) does not change the heart rate, cardiac output, mean pulmonary arterial blood pressure, systolic, diastolic and mean aortic blood pressure, respiratory rate and arterial blood gases, but mild to moderate depression is observed in five of eight horses administered i.v. Methocarbamol, and in all horses administered oral Methocarbamol. Plasma Methocarbamol concentration declines very rapidly during the initial or rapid disposition phase after i.v. administration; the terminal elimination half-life ranged from 59 minutes to 90 minutes in horse. Peak plasma Methocarbamol concentrations following oral administration occur within 15 to 45 minutes in horse. [3]

Synonyms	Lumirelax, AHR 85, Robaxin, Metocarbamol
Molecular Weight	241.243
Formula	C11H15NO5
CAS No.	532-03-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 45 mg/mL (186.5 mM)

Ethanol: 45 mg/mL (186.5 mM)

H2O: 2 mg/mL (8.29 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Rumpler MJ, et al. J Vet Pharmacol Ther, 2014, 37(1), 25-34. 2. Kuo K, et al. J Vet Emerg Crit Care (San Antonio), 2013, 23(4), 436-441. 3. Muir WW 3rd, et al. Equine Vet J Suppl, 1992, (11), 41-44.

Related compound libraries

This product is contained In the following compound libraries：

CNS-Penetrant Compound Library Bioactive Compound Library Anti-Cardiovascular Disease Compound Library Drug-Fragment Library Clinical Compound Library Glycometabolism Compound Library ReFRAME Related Library Human Metabolite Library Metabolism Compound Library Orally Active Compound Library

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Keywords

Methocarbamol 532-03-6 Membrane transporter/Ion channel Metabolism Sodium Channel Carbonic Anhydrase muscle relaxant Lumirelax inhibit AHR 85 Na channels central Inhibitor Robaxin Metocarbamol Na+ channels musculoskeletal inhibitor

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