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Magnesium Lithospermate B

Catalog No. T20793 CAS 122021-74-3

Synonyms: Monomethyl lithospermate B, Lithospermate B

Magnesium Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling.improves renal failure.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Magnesium Lithospermate B Chemical Structure

Magnesium Lithospermate B, CAS 122021-74-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 115.00
5 mg	In stock	$ 247.00
10 mg	In stock	$ 368.00
25 mg	In stock	$ 596.00
50 mg	In stock	$ 863.00
100 mg	In stock	$ 1,160.00
1 mL * 10 mM (in DMSO)	In stock	$ 395.00

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Purity: 99.87%

Purity: 98.61%

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Description	Magnesium Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling.improves renal failure.
In vitro	magnesium lithospermate B (MLB) dose-dependently inhibited the activation of microglia and reduced neuronal apoptosis.?Western blot analysis showed that MLB decreased the expression of inflammatory cytokine TNF- and pro-apoptotic protein cleaved caspase-3.?More importantly, MLB increased the expression of SIRT1, while inhibited the acetylation of NF-B.?Furthermore, pretreatment with sirtinol (a selective inhibitor of SIRT1) reversed all the aforementioned effects of MLB after SAH[1].
In vivo	magnesium lithospermate B (MLB), a bioactive ingredient extracted from Salvia miltiorrhiza, exerts neuroprotective effects in several central nervous system insults.administration of MLB significantly attenuated brain edema and neurological deficits after SAH[1].
Animal Research	Adult male Sprague-Dawley rats were subjected to an endovascular perforation process to produce an SAH model.?MLB was administrated intraperitoneally at 30min after SAH with a dose of 25mg/kg or 50mg/kg[1].
Source	Natural Products > Lamiaceae > Salvia

Synonyms	Monomethyl lithospermate B, Lithospermate B
Molecular Weight	740.9
Formula	C36H28MgO16
CAS No.	122021-74-3

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7.41 mg/mL (10 mM)

References and Literature

1. Yucong P , Pingyou H , Linfeng F , et al. Neuroprotective Effects of Magnesium Lithospermate B against Subarachnoid Hemorrhage in Rats[J]. The American Journal of Chinese Medicine, 2018, 46:1-17. 2. Zhang Z , Zichen W , Wei R , et al. Magnesium lithospermate B promotes proliferation and differentiation of neural stem cells in vitro and enhances neurogenesis in vivo[J]. Tissue & Cell, 2018, 53:8-14.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Bioactive Compound Library Anti-Aging Compound Library Covalent Inhibitor Library Bioactive Compounds Library Max Selected Plant-Sourced Compound Library Natural Product Library Immunology/Inflammation Compound Library Oxidation-Reduction Compound Library Food as Medicine Compound Library

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Keywords

Magnesium Lithospermate B 122021-74-3 Others tetramer oxidative cardiovascular Salviae neuroin?ammation miltiorrhizae inhibit Monomethyl lithospermate B acid Lithospermate B diseases caffeic Inhibitor damage inhibitor

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