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MK-8745

Catalog No. T2471 CAS 885325-71-3

MK-8745 is a potent and selective Aurora A inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MK-8745, CAS 885325-71-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 34.00
10 mg	In stock	$ 51.00
25 mg	In stock	$ 91.00
50 mg	In stock	$ 148.00
1 mL * 10 mM (in DMSO)	In stock	$ 38.00

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Purity: 99.31%

Purity: 99.09%

Purity: 98.94%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MK-8745 is a potent and selective Aurora A inhibitor.
Targets&IC50	Aurora A:0.6 nM
In vivo	MK-8745 induces apoptosis in a p53-dependent manner across various cell lines in vitro. Exposure of p53 wild-type cells to MK-8745 leads to the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression. This p53-dependent apoptotic effect of MK-8745 is further confirmed in HCT 116 p53 (-/-) cells transfected with wild-type p53. In non-Hodgkin's lymphoma cell lines, MK-8745 causes cell cycle arrest at the G2/M phase with the accumulation of tetraploid nuclei, followed by cell death. Treatment with MK-8745 induces p21 (waf1/cip1) and CycB1, indicating cell cycle arrest and an increased population of cells in the G2/M phase. Additionally, MK-8745 treatment leads to the rapid degradation of Aurora-A substrates (TACC3, Eg5, and TPX2) following the reduction of phospho-Aurora-A.

Molecular Weight	431.91
Formula	C20H19ClFN5OS
CAS No.	885325-71-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 1 mg/mL (2.31 mM)

DMSO: 80 mg/mL (185.2 mM)

References and Literature

1. Chowdhury A, et al. Leuk Lymphoma. 2012, 53(3), 462-471. 2. Nair JS, et al. Cell Cycle, 2012, 11(4), 807-817.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Highly Selective Inhibitor Library Inhibitor Library Cell Cycle Compound Library Target-Focused Phenotypic Screening Library Bioactive Compounds Library Max Anti-Cancer Compound Library Autophagy Compound Library Epigenetics Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MK-8745 885325-71-3 Apoptosis Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase MK8745 Inhibitor inhibit MK 8745 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.