store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 73.00 | |
5 mg | In stock | $ 158.00 | |
10 mg | In stock | $ 286.00 | |
25 mg | In stock | $ 485.00 | |
50 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 242.00 |
Description | MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively) |
Targets&IC50 | ERK2:8.8 nM, ERK1:23 nM |
In vitro | MK-8353 is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively); MK-8353 has antitumor activity. |
In vivo | MK-8353 causes at least 50% tumor growth inhibition or regression in 83% of the animal models bearing different tumor cells[1]. |
Synonyms | SCH900353 |
Molecular Weight | 691.84 |
Formula | C37H41N9O3S |
CAS No. | 1184173-73-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (180.68 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MK-8353 1184173-73-6 MAPK ERK Extracellular signal regulated kinases Inhibitor inhibit SCH 900353 SCH900353 SCH-900353 MK8353 MK 8353 inhibitor