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Luteolin

Catalog No. T1027 CAS 491-70-3

Synonyms: Luteolol, Flacitran, Digitoflavone, Luteoline

Luteolin (Luteolol) belongs to the flavonoid group of natural products and is a Nrf2 inhibitor, PDE inhibitor. Luteolin has a wide range of biological activities including antitumor, antioxidant, anti-inflammatory, antimicrobial, antiviral, antiallergic, and procoagulant.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Luteolin, CAS 491-70-3

Pack Size	Availability	Price/USD
10 mg	In stock	$ 39.00
50 mg	In stock	$ 45.00
100 mg	In stock	$ 55.00
200 mg	In stock	$ 86.00
500 mg	In stock	$ 148.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 98%

Purity: 97.39%

Purity: 96.61%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Luteolin (Luteolol) belongs to the flavonoid group of natural products and is a Nrf2 inhibitor, PDE inhibitor. Luteolin has a wide range of biological activities including antitumor, antioxidant, anti-inflammatory, antimicrobial, antiviral, antiallergic, and procoagulant.
Targets&IC50	PDE2:6.4 μM(Ki), PDE3:13.9 μM(Ki), PDE5:9.5 μM(Ki), PDE1:15.0 μM(Ki), PDE4:11.1 μM(Ki)
In vitro	METHODS: ESCC cell lines EC1, EC9706, KYSE30 and KYSE450 were treated with Luteolin (10-80 µM) for 48-72 h. Cell viability was measured using the CCK-8 Assay. RESULTS: Luteolin inhibited the growth of ESCC cell lines in a dose-dependent manner with IC50 in the range of 20-60 µM. [1] METHODS: Human cervical cancer cells, HeLa, were treated with Luteolin (5-20 µM) for 48 h. Cell cycle profiles were analyzed using Flow Cytometry. RESULTS: Luteolin treatment blocked the cell cycle progression of HeLa cells in sub-G1 phase. [2]
In vivo	METHODS: To detect anti-tumor activity in vivo, Luteolin (50 mg/kg) was injected intraperitoneally once daily for eighteen days into BALB/C-nu mice bearing ESCC tumor EC1. RESULTS: The Luteolin treatment group showed a reduction in tumor size and a reduction in total tumor weight of about 65%. [1] METHODS: To study the effect on intestinal mucositis, Luteolin (3-30 mg/kg in water plus 1% Tween) was administered by gavage or intraperitoneally to irinotecan-induced intestinal mucositis in Swiss mice once a day for fourteen days. RESULTS: Luteolin prevented irinotecan-induced intestinal damage by reducing weight loss and diarrhea scores as well as attenuating duodenal and colonic shortening. [3]

Synonyms	Luteolol, Flacitran, Digitoflavone, Luteoline
Molecular Weight	286.24
Formula	C15H10O6
CAS No.	491-70-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 57 mg/mL (199.13 mM)

Ethanol: 3 mg/mL (10.48 mM), Heating is recommended.

References and Literature

1. Chen P, et al. Luteolin inhibits cell proliferation and induces cell apoptosis via down-regulation of mitochondrial membrane potential in esophageal carcinoma cells EC1 and KYSE450. Oncotarget. 2017 Apr 18;8(16):27471-27480. 2. Raina R, et al. Luteolin inhibits proliferation, triggers apoptosis and modulates Akt/mTOR and MAP kinase pathways in HeLa cells. Oncol Lett. 2021 Mar;21(3):192. 3. Boeing T, et al. Luteolin prevents irinotecan-induced intestinal mucositis in mice through antioxidant and anti-inflammatory properties. Br J Pharmacol. 2020 May;177(10):2393-2408. 4. Dong J, Xu O, Wang J, et al. . Luteolin ameliorates inflammation and Th1/Th2 imbalance via regulating the TLR4/NF-κB pathway in allergic rhinitis rats[J]. Immunopharmacology and Immunotoxicology. 2021: 1-9 5. Ding X, Zheng L, Yang B, et al. Luteolin Attenuates Atherosclerosis Via Modulating Signal Transducer And Activator Of Transcription 3-Mediated Inflammatory Response[J]. Drug Des Devel Ther. 2019, 13: 3899. 6. Yang Y, Tan X, Xu J, et al. Luteolin alleviates neuroinflammation via downregulating the TLR4/TRAF6/NF-κB pathway after intracerebral hemorrhage[J]. Biomedicine & pharmacotherapy. 2020, 126: 110044. 7. Tan X, Yang Y, Xu J, et al. Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage[J]. Frontiers in Pharmacology. 2020, 10: 1551.

Citations

1. Tan X, Yang Y, Xu J, et al. Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage. Frontiers in Pharmacology. 2020, 10: 1551 2. Yang Y, Tan X, Xu J, et al. Luteolin alleviates neuroinflammation via downregulating the TLR4/TRAF6/NF-κB pathway after intracerebral hemorrhage. Biomedicine & Pharmacotherapy. 2020, 126: 110044 3. Zhang Y, Yu F, Hao J, et al. Study on the Effective Material Basis and Mechanism of Traditional Chinese Medicine Prescription (QJC) Against Stress Diarrhea in Mice. Frontiers in Veterinary Science. 2021, 8. 4. Ding X, Zheng L, Yang B, et al. Luteolin Attenuates Atherosclerosis Via Modulating Signal Transducer And Activator Of Transcription 3-Mediated Inflammatory Response. Drug Des Devel Ther. 2019, 13: 3899. 5. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet. Planta Medica. 2019, 85(14/15): 1128-1135 6. Xiao Z, Xu H, Qu Z, et al. Active Ingredients of Reduning Injections Maintain High Potency against SARS-CoV-2 Variants. Chinese Journal of Integrative Medicine. 2022: 1-8. 7. Dong J, Xu O, Wang J, et al. Luteolin ameliorates inflammation and Th1/Th2 imbalance via regulating the TLR4/NF-κB pathway in allergic rhinitis rats. Immunopharmacology and Immunotoxicology. 2021 Jun;43(3):319-327. doi: 10.1080/08923973.2021.1905659. Epub 2021 Apr 26. 8. Jung M A, Song H K, Jo K, et al.Gleditsia sinensis Lam. aqueous extract attenuates nasal inflammation in allergic rhinitis by inhibiting MUC5AC production through suppression of the STAT3/STAT6 pathway.Biomedicine & Pharmacotherapy.2023, 161: 114482. 9. Zhu Y, Bao G, Zhu G, et al.Discovery and characterization of natural product luteolin as an effective inhibitor of human pyridoxal kinase.Bioorganic Chemistry.2023: 107057.

Related compound libraries

This product is contained In the following compound libraries：

Miao medicine Compound Library Antiparasitic Natural Product Library Inhibitor Library Anti-Cancer Active Compound Library Tobacco Monomer Library Anti-Neurodegenerative Disease Compound Library Flavonoid Natural Product Library Natural Product Library Natural Product Library for HTS Food as Medicine Compound Library

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Keywords

Luteolin 491-70-3 Apoptosis Autophagy Immunology/Inflammation Metabolism Endogenous Metabolite Nrf2 PDE inhibit Keap1-Nrf2 Luteolol Flacitran Digitoflavone Inhibitor Luteoline inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.