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Lirequinil

Catalog No. T27838 CAS 143943-73-1

Synonyms: RO413696, RO-413696, RO41-3696, RO 413696, Ro 41-3696, Ro-41-3696

Lirequinil (Ro 41-3696) is a small molecule GABAA receptor agonist used to study neurological disorders.

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Lirequinil, CAS 143943-73-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 160.00
5 mg	In stock	$ 400.00
10 mg	In stock	$ 600.00
25 mg	In stock	$ 959.00
50 mg	In stock	$ 1,280.00
100 mg	In stock	$ 1,750.00
500 mg	In stock	$ 3,490.00

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Purity: 97.86%

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Description

Lirequinil (Ro 41-3696) is a small molecule GABAA receptor agonist used to study neurological disorders.

In vivo

In a double-blind, six-way crossover study of the effects on psychomotor performance and memory of single doses of Ro 41-3696 (Lirequinil) (1, 3, 5, and 10 mg), a novel non-benzodiazepine partial agonist at the benzodiazepine receptor, zolpidem (10 mg) and placebo were compared after night-time administration to 12 healthy young male subjects. Psychomotor performance tests (tracking and attention as part of a standardized task battery) were conducted just before and at 1.5 and 8 h after drug intake. The memory test consisted of the recall of a list of 15 words at 8 h after drug intake which had been learned at 1.5 h after intake. At 1.5 h after drug intake 10 mg zolpidem induced markedly larger psychomotor effects than any dose of Ro 41-3696. The effects of 5 and 10 mg Ro 41-3696 and zolpidem were significantly greater than those of placebo (P < 0.05). The following morning, 8 h after drug intake, the slight residual effects of 5 and 10 mg Ro 41-3696 were statistically significantly greater than placebo, whereas zolpidem effects did not differ from placebo. The results of the memory test showed that learning as well as recall was most clearly impaired by zolpidem. An influence of Ro 41-3696 on these variables was not observed for doses up to 5 mg. In conclusion, Ro 41-3696 at all doses tested induced fewer effects on psychomotor performance and memory than 10 mg zolpidem at 1.5 h after intake. However, the effects of Ro 41-3696 appeared to be of longer duration. [2]

Synonyms	RO413696, RO-413696, RO41-3696, RO 413696, Ro 41-3696, Ro-41-3696
Molecular Weight	448.94
Formula	C26H25ClN2O3
CAS No.	143943-73-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Dingemanse J, et al. Pharmacokinetics and pharmacodynamics of Ro 41-3696, a novel nonbenzodiazepine hypnotic. J Clin Pharmacol. 1995;35(8):821-829. 2. Dingemanse J, et al. Comparative pharmacodynamics of Ro 41-3696, a new hypnotic, and zolpidem after night-time administration to healthy subjects. Psychopharmacology (Berl). 1995;122(2):169-174. 3. Tsuboi M, et al. Changes in mouse hippocampal EEG characteristics after oral administration of Ro 41-3696, nitrazepam, or zopiclone alone and in combination with ethanol. Pharmacology. 1994;49(5):278-285. 4. Dingemanse J, et al. Multiple-dose tolerability, pharmacodynamics, and pharmacokinetics of the quinolizinone hypnotic Ro 41-3696 in elderly subjects. Clin Neuropharmacol. 2001;24(2):82-90.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Bioactive Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library

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Keywords

Lirequinil 143943-73-1 Membrane transporter/Ion channel Neuroscience GABA Receptor RO413696 RO-413696 RO41-3696 RO 413696 Ro 41-3696 Ro-41-3696 inhibitor inhibit

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