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Catalog No. T4532   CAS 1923833-60-6
Synonyms: BMS-986205

BMS-986205 is a selective indoleamine 2, 3-dioxygenase 1 (<a href="/target/IDO" style="display: inline; color: #c13a36">IDO</a>1) inhibitor.

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Linrodostat, CAS 1923833-60-6
Pack Size Availability Price/USD Quantity
5 mg In stock $ 64.00
10 mg In stock $ 94.00
25 mg In stock $ 183.00
50 mg In stock $ 298.00
100 mg In stock $ 477.00
200 mg In stock $ 645.00
1 mL * 10 mM (in DMSO) In stock $ 71.00
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Purity: 99.84%
Purity: 99.71%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description BMS-986205 is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
Targets&IC50 IDO1:1.7 nM (Cell-free)
In vitro BMS-986205 shows potent inhibition of kynurenine production in IDO1-HEK293 cells (IC50: 1.1 nM) but not in TDO-HEK293 cells[1].
Synonyms BMS-986205
Molecular Weight 410.92
Formula C24H24ClFN2O
CAS No. 1923833-60-6


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 15 mg/mL

DMSO: 25 mg/mL

H2O: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Lillian L. Siu, et al. Abstract CT116: BMS-986205, an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic (PD) activity, alone and in combination with nivolumab (nivo) in advanced cancers in a phase 1/2a trial. AACR; Cancer Res. 2017; 77 (13 Suppl): Abstract nr CT116.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library NO PAINS Compound Library Pediatric Drug Library Target-Focused Phenotypic Screening Library Anti-Cancer Metabolism Compound Library Bioactive Compound Library ReFRAME Related Library Clinical Compound Library Anti-Cancer Clinical Compound Library Anti-Metabolism Disease Compound Library

Related Products

Related compounds with same targets
BMS-986242 IDO1-IN-5 IACS-8968 S-enantiomer IACS-8968 R-enantiomer IACS-8968 IDO1-IN-2 IDO-IN-9 IDO-IN-8

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box


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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box


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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.


Linrodostat 1923833-60-6 Metabolism IDO Indoleamine 2,3-Dioxygenase (IDO) ONO 7701 BMS 986205 BMS986205 ONO-7701 inhibit Inhibitor ONO7701 BMS-986205 inhibitor