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Linrodostat

Catalog No. T4532 CAS 1923833-60-6

Synonyms: BMS-986205

BMS-986205 is a selective indoleamine 2, 3-dioxygenase 1 (<a href="/target/IDO" style="display: inline; color: #c13a36">IDO</a>1) inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Linrodostat, CAS 1923833-60-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 64.00
10 mg	In stock	$ 94.00
25 mg	In stock	$ 183.00
50 mg	In stock	$ 298.00
100 mg	In stock	$ 477.00
200 mg	In stock	$ 645.00
1 mL * 10 mM (in DMSO)	In stock	$ 71.00

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Purity: 99.84%

Purity: 99.71%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BMS-986205 is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
Targets&IC50	IDO1:1.7 nM (Cell-free)
In vitro	BMS-986205 shows potent inhibition of kynurenine production in IDO1-HEK293 cells (IC50: 1.1 nM) but not in TDO-HEK293 cells[1].

Synonyms	BMS-986205
Molecular Weight	410.92
Formula	C24H24ClFN2O
CAS No.	1923833-60-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 15 mg/mL

DMSO: 25 mg/mL

H2O: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Lillian L. Siu, et al. Abstract CT116: BMS-986205, an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic (PD) activity, alone and in combination with nivolumab (nivo) in advanced cancers in a phase 1/2a trial. AACR; Cancer Res. 2017; 77 (13 Suppl): Abstract nr CT116.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library NO PAINS Compound Library Pediatric Drug Library Target-Focused Phenotypic Screening Library Anti-Cancer Metabolism Compound Library Bioactive Compound Library ReFRAME Related Library Clinical Compound Library Anti-Cancer Clinical Compound Library Anti-Metabolism Disease Compound Library

Related Products

Related compounds with same targets

BMS-986242 IDO1-IN-5 IACS-8968 S-enantiomer IACS-8968 R-enantiomer IACS-8968 IDO1-IN-2 IDO-IN-9 IDO-IN-8

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Step Two: Enter the in vivo formulation

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Linrodostat 1923833-60-6 Metabolism IDO Indoleamine 2,3-Dioxygenase (IDO) ONO 7701 BMS 986205 BMS986205 ONO-7701 inhibit Inhibitor ONO7701 BMS-986205 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.