store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lenumlostat is an orally available, selective and potent lysyl oxidase-like protein 2 (LOXL2) inhibitor with inhibitory effects on hLOXL2, hLOXL3 and LOXL2 for the study of fibrotic diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 197.00 | |
5 mg | In stock | $ 497.00 | |
10 mg | In stock | $ 747.00 | |
25 mg | In stock | $ 1,490.00 | |
50 mg | In stock | $ 2,320.00 | |
100 mg | In stock | $ 3,320.00 | |
500 mg | In stock | $ 6,670.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 547.00 |
Description | Lenumlostat is an orally available, selective and potent lysyl oxidase-like protein 2 (LOXL2) inhibitor with inhibitory effects on hLOXL2, hLOXL3 and LOXL2 for the study of fibrotic diseases. |
Targets&IC50 | LOXL2:0.10 μM (Mouse), LOXL3 (human):1.17 μM, LOXL2 (human):0.71 μM, LOXL2:0.12 μM (Rat), LOXL2:0.16 μM (Dog) |
In vitro | Lenumlostat(PAT-1251)is a Lysyl Oxidase-Like 2 (LOXL2) inhibitor, with IC50s of 0.71 μM and 1.17 μM for hLOXL2 and hLOXL3, respectively. It also potently inhibits LOXL2 in mouse, rat, and dog, with IC50s of 0.10 μM, 0.12 μM, and 0.16 μM, respectively. Lenumlostat(PAT-1251) exhibits high selectivity for LOXL2 over other key members of the amine oxidase family, such as the copper-dependent amine oxidases semicarbazide-sensitive amine oxidase (SSAO) and diamine oxidase (DAO). Additionally, it shows selectivity against the flavin-dependent monoamine oxidases A (MAO-A) and B (MAO-B), with less than 10% inhibition at 10 μM[1]. |
Synonyms | PAT-1251, GB2064 |
Molecular Weight | 399.34 |
Formula | C18H17F4N3O3 |
CAS No. | 2098884-52-5 |
store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (200.33 mM), Sonication is recommended.
H2O: 80 mg/mL (200.33 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Lenumlostat 2098884-52-5 Neuroscience Monoamine Oxidase PAT-1251 GB2064 inhibitor inhibit